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Comprehensive Comparison between 222 CTLA-4 Haploinsufficiency and 212 LRBA Deficiency Patients: A Systematic Review
Clin Exp Immunol. 2021 Mar 31. doi: 10.1111/cei.13600. Online ahead of print.ABSTRACTCTLA-4 haploinsufficiency (CHAI) and LRBA deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to provide differential comparisons regarding demographic, clinical, immunologic, and molecular characteristics between these two similar conditions. A literature search was conducted in PubMed, Web of Science, and Scopus databases and included studies were systematically evaluated. Overall, 434 (222 CHAI and 212 LATAIE) patients were found i...
Source: Clinical and Developmental Immunology - March 31, 2021 Category: Allergy & Immunology Authors: Mahnaz Jamee Soheila Hosseinzadeh Niusha Sharifinejad Majid Zaki-Dizaji Mojdeh Matloubi Mahsa Hasani Safa Baris Mohamed Alsabbagh Bernice Lo Gholamreza Azizi Source Type: research
Disease-modifying treatments for primary autoimmune haemolytic anaemia
CONCLUSIONS: Available literature on the effectiveness of immunomodulatory therapy for primary AIHA is restricted to comparison between rituximab plus glucocorticoid and glucocorticoid alone, in patients with newly diagnosed warm AIHA, calling for need for additional studies. The current result suggests that combinatory therapy with rituximab and glucocorticoid may increase the rate of complete haematological response over glucocorticoid monotherapy.PMID:33786812 | DOI:10.1002/14651858.CD012493.pub2
Source: Cochrane Database of Systematic Reviews - March 31, 2021 Category: General Medicine Authors: Anthony Pak-Yin Liu Daniel Kl Cheuk Source Type: research
Comprehensive Comparison between 222 CTLA-4 Haploinsufficiency and 212 LRBA Deficiency Patients: A Systematic Review
Clin Exp Immunol. 2021 Mar 31. doi: 10.1111/cei.13600. Online ahead of print.ABSTRACTCTLA-4 haploinsufficiency (CHAI) and LRBA deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to provide differential comparisons regarding demographic, clinical, immunologic, and molecular characteristics between these two similar conditions. A literature search was conducted in PubMed, Web of Science, and Scopus databases and included studies were systematically evaluated. Overall, 434 (222 CHAI and 212 LATAIE) patients were found i...
Source: Clinical and Developmental Immunology - March 31, 2021 Category: Allergy & Immunology Authors: Mahnaz Jamee Soheila Hosseinzadeh Niusha Sharifinejad Majid Zaki-Dizaji Mojdeh Matloubi Mahsa Hasani Safa Baris Mohamed Alsabbagh Bernice Lo Gholamreza Azizi Source Type: research
Disease-modifying treatments for primary autoimmune haemolytic anaemia
CONCLUSIONS: Available literature on the effectiveness of immunomodulatory therapy for primary AIHA is restricted to comparison between rituximab plus glucocorticoid and glucocorticoid alone, in patients with newly diagnosed warm AIHA, calling for need for additional studies. The current result suggests that combinatory therapy with rituximab and glucocorticoid may increase the rate of complete haematological response over glucocorticoid monotherapy.PMID:33786812 | DOI:10.1002/14651858.CD012493.pub2
Source: Cochrane Database of Systematic Reviews - March 31, 2021 Category: General Medicine Authors: Anthony Pak-Yin Liu Daniel Kl Cheuk Source Type: research
Comprehensive Comparison between 222 CTLA-4 Haploinsufficiency and 212 LRBA Deficiency Patients: A Systematic Review
Clin Exp Immunol. 2021 Mar 31. doi: 10.1111/cei.13600. Online ahead of print.ABSTRACTCTLA-4 haploinsufficiency (CHAI) and LRBA deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to provide differential comparisons regarding demographic, clinical, immunologic, and molecular characteristics between these two similar conditions. A literature search was conducted in PubMed, Web of Science, and Scopus databases and included studies were systematically evaluated. Overall, 434 (222 CHAI and 212 LATAIE) patients were found i...
Source: Clinical and Developmental Immunology - March 31, 2021 Category: Allergy & Immunology Authors: Mahnaz Jamee Soheila Hosseinzadeh Niusha Sharifinejad Majid Zaki-Dizaji Mojdeh Matloubi Mahsa Hasani Safa Baris Mohamed Alsabbagh Bernice Lo Gholamreza Azizi Source Type: research
Disease-modifying treatments for primary autoimmune haemolytic anaemia
CONCLUSIONS: Available literature on the effectiveness of immunomodulatory therapy for primary AIHA is restricted to comparison between rituximab plus glucocorticoid and glucocorticoid alone, in patients with newly diagnosed warm AIHA, calling for need for additional studies. The current result suggests that combinatory therapy with rituximab and glucocorticoid may increase the rate of complete haematological response over glucocorticoid monotherapy.PMID:33786812 | DOI:10.1002/14651858.CD012493.pub2
Source: Cochrane Database of Systematic Reviews - March 31, 2021 Category: General Medicine Authors: Anthony Pak-Yin Liu Daniel Kl Cheuk Source Type: research
Comprehensive Comparison between 222 CTLA-4 Haploinsufficiency and 212 LRBA Deficiency Patients: A Systematic Review
Clin Exp Immunol. 2021 Mar 31. doi: 10.1111/cei.13600. Online ahead of print.ABSTRACTCTLA-4 haploinsufficiency (CHAI) and LRBA deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to provide differential comparisons regarding demographic, clinical, immunologic, and molecular characteristics between these two similar conditions. A literature search was conducted in PubMed, Web of Science, and Scopus databases and included studies were systematically evaluated. Overall, 434 (222 CHAI and 212 LATAIE) patients were found i...
Source: Clinical and Developmental Immunology - March 31, 2021 Category: Allergy & Immunology Authors: Mahnaz Jamee Soheila Hosseinzadeh Niusha Sharifinejad Majid Zaki-Dizaji Mojdeh Matloubi Mahsa Hasani Safa Baris Mohamed Alsabbagh Bernice Lo Gholamreza Azizi Source Type: research
Disease-modifying treatments for primary autoimmune haemolytic anaemia
CONCLUSIONS: Available literature on the effectiveness of immunomodulatory therapy for primary AIHA is restricted to comparison between rituximab plus glucocorticoid and glucocorticoid alone, in patients with newly diagnosed warm AIHA, calling for need for additional studies. The current result suggests that combinatory therapy with rituximab and glucocorticoid may increase the rate of complete haematological response over glucocorticoid monotherapy.PMID:33786812 | DOI:10.1002/14651858.CD012493.pub2
Source: Cochrane Database of Systematic Reviews - March 31, 2021 Category: General Medicine Authors: Anthony Pak-Yin Liu Daniel Kl Cheuk Source Type: research
Comprehensive Comparison between 222 CTLA-4 Haploinsufficiency and 212 LRBA Deficiency Patients: A Systematic Review
Clin Exp Immunol. 2021 Mar 31. doi: 10.1111/cei.13600. Online ahead of print.ABSTRACTCTLA-4 haploinsufficiency (CHAI) and LRBA deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to provide differential comparisons regarding demographic, clinical, immunologic, and molecular characteristics between these two similar conditions. A literature search was conducted in PubMed, Web of Science, and Scopus databases and included studies were systematically evaluated. Overall, 434 (222 CHAI and 212 LATAIE) patients were found i...
Source: Clinical and Developmental Immunology - March 31, 2021 Category: Allergy & Immunology Authors: Mahnaz Jamee Soheila Hosseinzadeh Niusha Sharifinejad Majid Zaki-Dizaji Mojdeh Matloubi Mahsa Hasani Safa Baris Mohamed Alsabbagh Bernice Lo Gholamreza Azizi Source Type: research
Disease-modifying treatments for primary autoimmune haemolytic anaemia
CONCLUSIONS: Available literature on the effectiveness of immunomodulatory therapy for primary AIHA is restricted to comparison between rituximab plus glucocorticoid and glucocorticoid alone, in patients with newly diagnosed warm AIHA, calling for need for additional studies. The current result suggests that combinatory therapy with rituximab and glucocorticoid may increase the rate of complete haematological response over glucocorticoid monotherapy.PMID:33786812 | DOI:10.1002/14651858.CD012493.pub2
Source: Cochrane Database of Systematic Reviews - March 31, 2021 Category: General Medicine Authors: Anthony Pak-Yin Liu Daniel Kl Cheuk Source Type: research
Comprehensive Comparison between 222 CTLA-4 Haploinsufficiency and 212 LRBA Deficiency Patients: A Systematic Review
Clin Exp Immunol. 2021 Mar 31. doi: 10.1111/cei.13600. Online ahead of print.ABSTRACTCTLA-4 haploinsufficiency (CHAI) and LRBA deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to provide differential comparisons regarding demographic, clinical, immunologic, and molecular characteristics between these two similar conditions. A literature search was conducted in PubMed, Web of Science, and Scopus databases and included studies were systematically evaluated. Overall, 434 (222 CHAI and 212 LATAIE) patients were found i...
Source: Clinical and Developmental Immunology - March 31, 2021 Category: Allergy & Immunology Authors: Mahnaz Jamee Soheila Hosseinzadeh Niusha Sharifinejad Majid Zaki-Dizaji Mojdeh Matloubi Mahsa Hasani Safa Baris Mohamed Alsabbagh Bernice Lo Gholamreza Azizi Source Type: research
