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Specialty: Cardiology
Drug: Tamoxifen

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Total 55 results found since Jan 2013.

Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research

Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
CONCLUSION: Whole-body AT1R inhibition reduced atherosclerosis equivalently in both male and female mice; however, PTC-specific manipulation of the RAS components had no effects on hypercholesterolemia-induced atherosclerosis.PMID:37655218 | PMC:PMC10466789 | DOI:10.3389/fcvm.2023.1250234
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Masayoshi Kukida Naofumi Amioka Dien Ye Hui Chen Jessica J Moorleghen Ching-Ling Liang Deborah A Howatt Yuriko Katsumata Motoko Yanagita Hisashi Sawada Alan Daugherty Hong S Lu Source Type: research

Endothelial Cell < em > APOE3 < /em > Regulates Neurovascular, Neuronal, and Behavioral Function
CONCLUSIONS: Our data collectively support the novel concept that endothelial APOE3 plays a critical role in the regulation of the neurovasculature, neural circuit function, and behavior.PMID:37650329 | DOI:10.1161/ATVBAHA.123.319816
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 31, 2023 Category: Cardiology Authors: Felecia M Marottoli Hui Zhang Eden Flores-Barrera Emilce Artur de la Villarmois Frederick C Damen Anabel M M Miguelez Fern ández Hannah V Blesson Rohan Chaudhary Anthony L Nguyen Amanda E Nwokeji Ruju Talati Ashwin S John Kushi Madadakere Sarah E Lutz Ke Source Type: research