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Specialty: Genetics & Stem Cells
Drug: Tamoxifen
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Total 65 results found since Jan 2013.
The G-protein-coupled estrogen receptor, a gene co-expressed with ER α in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cells
In conclusion, GPER is positively associated with ERα in breast tumors, and induced by estrogen-ERα signalling axis. Estrogen-mediated induction of GPER makes the cells more responsive to GPER ligands. More in-depth studies are warranted to establish the significance of GPER-ERα co-expression, and their interplay in breast tumor development, progression, and treatment.PMID:37279863 | DOI:10.1016/j.gene.2023.147548
Source: Gene - June 6, 2023 Category: Genetics & Stem Cells Authors: Uttariya Pal Mohan C Manjegowda Neha Singh Snigdha Saikia Betty S Philip Deep Jyoti Kalita Avdhesh Kumar Rai Anupam Sarma Vandana Raphael Deepak Modi Amal Chandra Kataki Anil Mukund Limaye Source Type: research
Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL
Genomics Proteomics Bioinformatics. 2023 Feb 10:S1672-0229(23)00032-3. doi: 10.1016/j.gpb.2023.01.006. Online ahead of print.ABSTRACTPrediction of the response of cancer patients to different treatments and identification of biomarkers of drug response are two major goals of individualized medicine. Here, we developed a deep learning framework called TINDL, completely trained on preclinical cancer cell lines (CCLs), to predict the response of cancer patients to different treatments. TINDL utilizes a tissue-informed normalization to account for the tissue type and cancer type of the tumors and to reduce the statistical disc...
Source: Genomics Proteomics ... - February 12, 2023 Category: Genetics & Stem Cells Authors: David Earl Hostallero Lixuan Wei Liewei Wang Junmei Cairns Amin Emad Source Type: research
Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells
Gene. 2022 Nov 13:147049. doi: 10.1016/j.gene.2022.147049. Online ahead of print.ABSTRACTA cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducible CreERT2 transgenic (Tg) mouse employing previously identified hematopoietic stem cell (HSC) enhancer for Runx1, eR1 (+24m). Kinetic analysis of labeled cells after tamoxifen injection and transplantation assays revealed that eR1-driven CreERT2 activity marks dormant adult HSCs which slowl...
Source: Gene - November 17, 2022 Category: Genetics & Stem Cells Authors: Cai Ping Koh Avinash Govind Bahirvani Chelsia Qiuxia Wang Tomomasa Yokomizo Cherry Ee Lin Ng Linsen Du Vinay Tergaonkar Dominic Chih-Cheng Voon Hiroaki Kitamura Hiroki Hosoi Takashi Sonoki Mok Meng Huang Michelle Lii Jye Tan Akiko Niibori-Nambu Yi Zhang A Source Type: research
Genome-wide post-transcriptional regulation of bovine mammary gland response to Streptococcus uberis
In this study, a system biology approach was used to better understand the main post-transcriptional regulatory functions and elements of bovine mammary gland response to Str. uberis infection. Publicly available miRNA-Seq data containing 50 milk samples of the ten dairy cows (five controls and five infected) were retrieved for this current research. Functional enrichment analysis of predicted targets revealed that highly confident responsive miRNAs (4 up- and 19 downregulated) mainly regulate genes involved in the regulation of transcription, apoptotic process, regulation of cell adhesion, and pro-inflammatory signaling p...
Source: J Appl Genet - September 6, 2022 Category: Genetics & Stem Cells Authors: Raana Tabashiri Somayeh Sharifi Abbas Pakdel Mohammad Reza Bakhtiarizadeh Mohammad Hosein Pakdel Ahmad Tahmasebi Colin Hercus Source Type: research
Phylogenomic and expression analysis of Colossoma macropomum cyp19a1a and cyp19a1b and their non-classical role in tambaqui sex differentiation
In this study, we combined in silico analysis, real-time quantitative PCR (qPCR) assay and quantification of E2 plasma levels of differentiating tambaqui (Colossoma macropomum) to unveil the roles of the paralogs cypa19a1a and cyp19a1b during sex differentiation. Although the synteny of each gene is very conserved among characids, the genomic environment displays striking differences in comparison to model teleost species, with many rearrangements in cyp19a1a and cyp19a1b adjacencies and transposable element traces in both regulatory regions. The high dissimilarity (DI) of SF-1 binding motifs in cyp19a1a (DI=10.06 to 14.90...
Source: Gene - August 12, 2022 Category: Genetics & Stem Cells Authors: R V Paix ão G F Silva A R Caetano L Cintra Varela Eduardo F L A O'Sullivan Source Type: research
Global transcriptome analysis reveals partial estrogen-like effects of karanjin in MCF-7 breast cancer cells
Gene. 2022 Apr 18:146507. doi: 10.1016/j.gene.2022.146507. Online ahead of print.ABSTRACTKaranjin, an abundantly occurring furanoflavonoid in edible and non-edible legumes, exerts diverse biological effects in vivo, and in vitro. Its potential as an anticancer agent is gaining traction following recent demonstrations of its anti-proliferative, cell cycle inhibitory, and pro-apoptotic effects. However, the genomic correlates of these activities are not known. In the present study we delineated the transcriptomic footprint of 10 μM karanjin in MCF-7 breast cancer cells, using next generation sequencing technology (RNA-seq)....
Source: Gene - April 21, 2022 Category: Genetics & Stem Cells Authors: Gaurav Bhatt Akshita Gupta Latha Rangan Anil Mukund Limaye Source Type: research
Estrogen Receptor Gene Polymorphism as a Possible Genetic Risk Factor for Treatment Response in ER-Positive Breast Cancer Patients
Biochem Genet. 2022 Feb 19. doi: 10.1007/s10528-022-10199-3. Online ahead of print.ABSTRACTEstrogen receptor-α (ESR1) single nucleotide polymorphisms (SNPs) have been related to breast cancer (BC) susceptibility. In this retrospective study we investigated ESR1 SNPs in association with survival and treatment response in BC patients. Seven ESR1 SNPs were genotyped using TaqMan probe assay in 100 formalin-fixed paraffin embedded blocks of Egyptian ER+BC patients. Log-binomial regression was used to assess the association of 5 ESR1 SNPs with relative risk of non-response to adjuvant-hormonal treatment. We compared the perfor...
Source: Biochemical Genetics - February 19, 2022 Category: Genetics & Stem Cells Authors: Nasr M A Allahloubi Abdel-Rahman N Zekri Mohamed Ragab Marwa Mohanad Ola S Ahmed Salem Eid Mohamed Ghareeb Iman Gouda Abeer A Bahnassy Source Type: research
