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Specialty: Cytology
Drug: Tamoxifen
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Total 114 results found since Jan 2013.
Genetic inactivation of β-catenin is salubrious whereas its activation is deleterious in desmoplakin cardiomyopathy
CONCLUSION: The cWNT/β-catenin was markedly dysregulated in the cardiac myocytes in a mouse model of desmoplakin cardiomyopathy. Inactivation of β-catenin attenuated whereas its activation aggravated the phenotype, through multiple molecular pathways, independent of the cWNT transcriptional activity. Thus, suppression but not activation of β-catenin might be beneficial in desmoplakin cardiomyopathy.PMID:37625794 | DOI:10.1093/cvr/cvad137
Source: Cell Research - August 25, 2023 Category: Cytology Authors: Melis Olcum Siyang Fan Leila Rouhi Sirisha Cheedipudi Benjamin Cathcart Hyun-Hwan Jeong Zhongming Zhao Priyatansh Gurha Ali J Marian Source Type: research
Resistance to hormone therapy in breast cancer cells promotes autophagy and EGFR signaling pathway
Am J Physiol Cell Physiol. 2023 Aug 14. doi: 10.1152/ajpcell.00199.2023. Online ahead of print.ABSTRACTBreast cancer is the leading cause of cancer deaths for women worldwide. Endocrine therapies represent the cornerstone for hormone-dependent breast cancer treatment. However, in many cases, endocrine resistance is induced with poor prognosis for patients. In the current study, we have developed MCF-7 cell lines resistant to Fulvestrant (MCF-7Fulv) and Tamoxifen (MCF-7Tam) aiming at investigating mechanisms underlying resistance. Both resistant cell lines exerted lower proliferation capacity in 2D cultures but retain ERα ...
Source: Am J Physiol Cell Ph... - August 14, 2023 Category: Cytology Authors: Konstantinos E Siatis Efstathia Giannopoulou Dimitra Manou Panagiotis Sarantis Michalis V Karamouzis Sofia Raftopoulou Konstantinos Fasseas Fatimah Mohammed Alzahrani Haralabos P Kalofonos Achilleas D Theocharis Source Type: research
Effect of Tamoxifen on Proteome Expression during < em > In Vitro < /em > Myogenesis in Murine Skeletal Muscle C < sub > 2 < /sub > C < sub > 12 < /sub > Cells
We report a tandem mass-tag approach to TMX-treated myogenesis in C2C12 cells, a well-characterized model of in vitro murine skeletal muscle differentiation. A longitudinal analysis of >10,000 proteins identified in untreated C2C12 myogenesis revealed a novel subset of 1,062 myogenically regulated proteins. These proteins clustered into five distinct longitudinal expression trends which significantly overlap those obtained in similar analyses performed in human myocytes. We document a specific functional enrichment for adiponectin-signaling unique to TMX-treated myogenesis, as well as a subset of 198 proteins that are d...
Source: Cell Research - August 8, 2023 Category: Cytology Authors: Emily A Morris Ahlenne Abreu Stylianos P Scordilis Source Type: research
Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
In this study, we applied in vivo fluorescent tracing using NestinCreERT2::Rosa26-tdTomato mice and analyzed the endogenous neurogenesis lineage progression of neural stem cells (NSCs) and dendritic spine formation of newborn neurons in the subgranular zone of the dentate gyrus. We found abnormal orientation of tamoxifen-induced tdTomato+ (tdTom+) NSCs in adult mice 2 months after treatment with EtOH (5.0 g/kg, i.p.) for 7 consecutive days. EtOH markedly inhibited tdTom+ NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to adulthood. EtOH (100 mM) also significantly inhibited the prolifer...
Source: Cell Research - July 25, 2023 Category: Cytology Authors: Guixiang Wang Wenjia Wang Ye Zhang Xiaoying Gou Qingqing Zhang Yanmiao Huang Kuo Zhang Haotian Zhang Jingyu Yang Yuting Li Source Type: research
