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Adherence to Adjuvant Endocrine Therapy and Survival Among Older Women with Early-Stage Hormone Receptor-Positive Breast Cancer
CONCLUSIONS: Patients who initiated with tamoxifen had a steeper decrease in adherence over the 5 years compared with anastrozole, letrozole, and exemestane groups. Furthermore, higher adherence was associated with a decreased risk of mortality. Physicians should be cognizant of decreasing adherence over time and choose effective treatment options with minimal side-effect profiles to better support adherence by patients with breast cancer.PMID:36740664 | DOI:10.1007/s40261-023-01247-w
Source: Clinical Genitourinary Cancer - February 5, 2023 Category: Cancer & Oncology Authors: Chanhyun Park Ji-Haeng Heo Sanica Mehta Sola Han Jennifer C Spencer Source Type: research

Machine Learning to Predict Tamoxifen Nonadherence Among US Commercially Insured Patients With Metastatic Breast Cancer
CONCLUSION: ML using baseline administrative data predicts tamoxifen nonadherence. Screening at treatment initiation may support personalized care, improve health outcomes, and minimize cost. Baseline claims may not be sufficient to discriminate adherence. Further validation with enriched longitudinal data may improve model performance.PMID:34383580 | DOI:10.1200/CCI.20.00102
Source: Clinical Breast Cancer - August 12, 2021 Category: Cancer & Oncology Authors: Gayathri Yerrapragada Athanasios Siadimas Amir Babaeian Vishakha Sharma Tyler J O'Neill Source Type: research