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Source: Endocrinology
Drug: Tamoxifen
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Total 32 results found since Jan 2013.
Bone-Derived IGF-I Regulates Radial Bone Growth in Adult Male mice
In conclusion, inactivation of IGF-I in cortical bone with unchanged liver-derived IGF-I in older male mice resulted in reduced radial growth of cortical bone. This suggests that not only circulating IGF-I, but also locally derived IGF-I, regulates the cortical bone phenotype in older mice.PMID:37406213 | DOI:10.1210/endocr/bqad104
Source: Endocrinology - July 5, 2023 Category: Endocrinology Authors: Johan Svensson Klara Sj ögren Lina Lawenius Antti Koskela Juha Tuukkanen Karin H Nilsson Sofia Mov érare-Skrtic Claes Ohlsson Source Type: research
NAD + Metabolism Generates a Metabolic Vulnerability in Endocrine-Resistant Metastatic Breast Tumors in Females
In this study, we identified NAMPT, an important enzyme in nicotinamide adenine dinucleotide (NAD+) metabolism, to be increased in metastatic breast cancer (MBC) cells treated with Fulv. We tested whether the blockade of NAD+ production via inhibition of nicotinamide phosphoribosyltransferase (NAMPT) synergizes with standard-of-care therapies for ER+ metastatic breast cancer in vitro and in vivo. A synergistic effect was not observed when KPT-9274 was combined with palbociclib or tamoxifen or when Fulv was combined with other metabolic inhibitors. We show that NAMPT inhibitor KPT-9274 and fulvestrant (Fulv) works synergist...
Source: Endocrinology - May 12, 2023 Category: Endocrinology Authors: Ayca Nazli Mogol Qianying Zuo Jin Young Yoo Alanna Zoe Kaminsky Ozan Berk Imir Yosef Landesman Christopher J Walker Zeynep Madak Erdogan Source Type: research
Intestinal Vitamin D Receptor is Dispensable for Maintaining Adult Bone Mass in Mice with Adequate Calcium Intake
Endocrinology. 2023 Mar 24:bqad051. doi: 10.1210/endocr/bqad051. Online ahead of print.ABSTRACT1,25(OH)2D3-mediated intestinal calcium (Ca) absorption supplies Ca for proper bone mineralization during growth. We tested whether vitamin D receptor (VDR)-mediated 1,25(OH)2D3 signaling is critical for adult Ca absorption and bone by using mice with inducible Vdr gene knockout in the whole intestine (villin-CreERT2+/- x VDRf/f, WIK) or in the large intestine (CDX2-CreERT2+/-x VDRf/f, LIK). At 4-month-old, Vdr alleles were recombined (0.05 mg tamoxifen/g BW, i.p., 5-d) and mice were fed diets with either 0.5% (adequate) or 0.2% ...
Source: Endocrinology - March 24, 2023 Category: Endocrinology Authors: Heng Jiang Krittikan Chanpaisaeng Sylvia Christakos James C Fleet Source Type: research
ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice
Endocrinology. 2022 Oct 26:bqac181. doi: 10.1210/endocr/bqac181. Online ahead of print.ABSTRACTLactotropes are prolactin (PRL)-secreting endocrine cells in anterior pituitary. We have established the zinc finger protein ZBTB20 as an essential transcription factor for lactotrope specification, the disruption of which results in complete loss of lactotropes in mice. However, the potential role of ZBTB20 in mature lactotropes remains unclear. Here we demonstrate that ZBTB20 acts as a critical cell-autonomous regulator for PRL expression in mature lactotropes in adult mice. Via a CRISPR/Cas9 approach, we first generated a tamo...
Source: Endocrinology - October 26, 2022 Category: Endocrinology Authors: Qing Han Xuede Yan Yufei Ye Linhui Han Xianhua Ma Ting Wang Dongmei Cao Weiping J Zhang Source Type: research
Mammary tumor growth and proliferation are dependent on growth hormone in female SV40 C3(1) T-antigen mice
Endocrinology. 2022 Oct 21:bqac174. doi: 10.1210/endocr/bqac174. Online ahead of print.ABSTRACTFemale SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH) signaling in these tumors, genetic crosses were used to create cohorts of female mice that were homozygous for a floxed growth hormone receptor (Ghr) gene and carried one copy each of the Rosa-Cre-ERT2 transgene and the C3(1)/TAg transgene (Ghrflox/flox; Rosa-Cre-ERT2; C3(1)/TAg+/0 mice). When the ...
Source: Endocrinology - October 21, 2022 Category: Endocrinology Authors: Christopher J Unterberger Stephanie M McGregor John J Kopchick Steven M Swanson Paul C Marker Source Type: research
Foxe1 Deletion in the Adult Mouse is Associated with Increased Thyroidal Mast Cells and Hypothyroidism
CONCLUSIONS: Foxe1 deletion in adult mice was associated with disruption in thyroid follicular architecture accompanied by biochemical hypothyroidism, confirming its role in maintenance of thyroid differentiation. An unanticipated finding was an increase in thyroidal mast cells. These data suggest a possible explanation for previous human genetic studies associating alleles in/near FOXE1 with hypothyroidism and/or autoimmune thyroiditis.PMID:36156081 | DOI:10.1210/endocr/bqac158
Source: Endocrinology - September 26, 2022 Category: Endocrinology Authors: Grace Lim Alexander Widiapradja Scott P Levick Kelly J McKelvey Xiao Hui Liao Samuel Refetoff Martyn Bullock Roderick J Clifton-Bligh Source Type: research
