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Influenza A: H1N1 post-viral membranoproliferative glomerulonephritis occurring in aggressive systemic mastocytosis: Case report and literature review
Nephrol Ther. 2021 Oct 26:S1769-7255(21)00528-9. doi: 10.1016/j.nephro.2021.08.002. Online ahead of print.ABSTRACTSystemic mastocytosis is characterised by tissular infiltration and a cytokine storm due to mast cells excessive proliferation and activation. Herein, we report an extraordinary case of AH1N1 influenza post-viral glomerulonephritis occurring in the course of an aggressive systemic mastocytosis with an associated hematological neoplasm. Because of a multisystemic involvement including the liver and lungs, we treated mastocytosis with midostaurin (multiple inhibitor of kinase protein), anti H1/H2 blockers and dex...
Source: Nephrologie and Therapeutique - October 30, 2021 Category: Urology & Nephrology Authors: Quentin Bodard Patricia Rullier H élène Perrochia Moglie Le Quintrec M élissa Alamé Olivier Hermine Philippe Guilpain Alexandre Maria Source Type: research

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?
Cytokine. 2021 May 26:155593. doi: 10.1016/j.cyto.2021.155593. Online ahead of print.ABSTRACTAn analysis of published data appertaining to the cytokine storms of COVID-19, H1N1 influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) reveals many common immunological and biochemical abnormalities. These include evidence of a hyperactive coagulation system with elevated D-dimer and ferritin levels, disseminated intravascular coagulopathy (DIC) and microthrombi coupled with an activated and highly permeable vascular endothelium. Common immune abnormalities include progressive hypercytokinemia with...
Source: Cytokine - June 2, 2021 Category: Molecular Biology Authors: Gerwyn Morris Chiara C Bortolasci Basant K Puri Wolfgang Marx Adrienne O'Neil Eugene Athan Ken Walder Michael Berk Lisa Olive Andre F Carvalho Michael Maes Source Type: research