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Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study
CMAJ Open. 2022 Apr 19;10(2):E379-E389. doi: 10.9778/cmajo.20210216. Print 2022 Apr-Jun.ABSTRACTBACKGROUND: There have been multiple waves in the COVID-19 pandemic in many countries. We sought to compare mortality and respiratory, cardiovascular and renal dysfunction between waves in 3 Canadian provinces.METHODS: We conducted a substudy of the ARBs CORONA I study, a multicentre Canadian pragmatic observational cohort study that examined the association of pre-existing use of angiotensin receptor blockers with outcomes in adults admitted to hospital with acute COVID-19 up to April 2021 from 9 community and teaching hospital...
Source: cmaj - April 20, 2022 Category: General Medicine Authors: Terry Lee Matthew P Cheng Donald C Vinh Todd C Lee Karen C Tran Brent W Winston David Sweet John H Boyd Keith R Walley Greg Haljan Allison McGeer Fran çois Lamontagne Robert Fowler David Maslove Joel Singer David M Patrick John C Marshall Kevin D Burns S Source Type: research

A retrospective evaluation of the steroid sparing effects of oral mycophenolate mofetil (MMF) as an adjunct immunosuppressant for the treatment of canine pemphigus foliaceus
CONCLUSION: Oral MMF combined with GC achieved CR in 2 out of 11 PF dogs included in this study. Further research of MMF efficacy in PF may need to be performed.PMID:34697841 | DOI:10.1111/vde.13028
Source: Veterinary Dermatology - October 26, 2021 Category: Veterinary Research Authors: Andhika Putra Michaela Austel Frane Banovic Source Type: research

LITFL Review 227
Welcome to the 227th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM. The Most Fair Dinkum Ripper Beauts of the Week The old and new titans of critical care Paul Marik and Rob MacSweeney throw down over the futility of predicting fluid responsiveness in resuscitation. [JS] Natalie May provides a thought-provoking post looking at our polarised perspectives in th...
Source: Life in the Fast Lane - April 17, 2016 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs