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Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries
We described the demographics, clinical characteristics, biochemical features, and outcome of nitrofurantoin-induced liver injury. We analyzed 23 cases from the Latin American DILI Network (LATINDILI) and the Spanish DILI Registry. Causality was assessed with the RUCAM and RECAM scale. Of the 23 DILI cases included in our series, 96% patients were women, and the mean age of the whole cohort was 61 years. The median time of drug exposure was 175 days (interquartile range [IQR] 96-760), with 11 patients who were prescribed nitrofurantoin for more than six months. Hepatocellular damage was the most frequent pattern of liver i...
Source: Archives of Toxicology - November 23, 2022 Category: Toxicology Authors: Fernando Bessone Antonella Ferrari Nelia Hernandez Manuel Mendizabal Ezequiel Ridruejo Alina Zerega Federico Tanno Maria Virginia Reggiardo Julio Vorobioff Hugo Tanno Marco Arrese Vinicius Nunes Martin Tagle Inmaculada Medina-Caliz Mercedes Robles-Diaz Ha Source Type: research

Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury
CONCLUSION: NTF-DILI can result in parenchymal necrosis, bridging fibrosis, cirrhosis, and death or liver transplantation, especially with long-term exposure, and is associated with HLA-DRB1*11:04. For mitigating against serious liver injury associated with NTF, the regulators should revise the prescribing information and consider other mitigation strategies.LAY SUMMARY: Liver injury due to nitrofurantoin (NTF) exhibits two patterns: one with short-term exposure and another with long-term exposure. Liver injury due to short-term NTF exposure resembles acute hepatitis, with a low frequency of autoantibodies and benign outco...
Source: Cancer Control - September 24, 2022 Category: Cancer & Oncology Authors: Naga Chalasani Yi-Ju Li Andrew Dellinger Victor Navarro Herbert Bonkovsky Robert J Fontana Jiezhun Gu Huiman Barnhart Elizabeth Phillips Craig Lammert Tae-Hwi Schwantes-An Paola Nicoletti David E Kleiner Jay H Hoofnagle Drug Induced Liver Injury Network Source Type: research

Drug-induced autoimmune hepatitis: A minireview
World J Gastroenterol. 2022 Jun 28;28(24):2654-2666. doi: 10.3748/wjg.v28.i24.2654.ABSTRACTDrug-induced autoimmune hepatitis (DIAIH) is a specific phenotype of drug-induced liver injury that may lead to the devastating outcome of acute liver failure requiring liver transplantation. Drugs implicated in DIAIH include antimicrobials such as nitrofurantoin and minocycline, non-steroidal anti-inflammatory drugs, statins as well as anti-tumor necrosis agents. The clinical features of drug-induced liver injury are indistinguishable from idiopathic autoimmune hepatitis (AIH) as both may have positive AIH-related autoantibodies, el...
Source: World Journal of Gastroenterology : WJG - August 18, 2022 Category: Gastroenterology Authors: Chin Kimg Tan Danielle Ho Lai Mun Wang Rahul Kumar Source Type: research

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