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Drug: Polyethylene Glycol
Nutrition: Vitamin E
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Total 44 results found since Jan 2013.
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
Hyperoside Nanomicelles Alleviate Atherosclerosis by Modulating the Lipid Profile and Intestinal Flora Structure in High-Fat-Diet-Fed Apolipoprotein-E-Deficient Mice
Molecules. 2023 Jun 29;28(13):5088. doi: 10.3390/molecules28135088.ABSTRACTAtherosclerosis (AS) is a serious threat to human health and the main pathological basis of cardiovascular disease. Hyperoside (Hyp), a flavonoid found mainly in traditional Chinese herbs, can exert antitumor, anti-inflammatory, antioxidant, and cardiovascular-protective effects. Herein, we prepared hybrid nanomicelles (HFT) comprising Hyp loaded into pluronic F-127 and polyethylene glycol 1000 vitamin E succinate and assessed their effects on AS. To establish an AS model, apolipoprotein-E-deficient (ApoE-/-) mice were fed a high-fat diet. We then a...
Source: Atherosclerosis - July 14, 2023 Category: Cardiology Authors: Yuwen Shi Mengcheng Jiang Yuhang Zhang Yuanyuan Diao Na Li Weipeng Liu Zhidong Qiu Ye Qiu Ailing Jia Source Type: research
Preparation of an ophthalmic formulation of TPGS-modified insulin-loaded liposomes and its < em > in vitro < /em > corneal permeation and pharmacokinetics in rabbit eyes
CONCLUSION: The prepared T-LPs/INS shows an improved corneal permeability, ocular surface retention capacity and eye tissue concentration of insulin in rabbits.PMID:37313826 | PMC:PMC10267244 | DOI:10.12122/j.issn.1673-4254.2023.05.20
Source: Journal of Southern Medical University - June 14, 2023 Category: Universities & Medical Training Authors: D Zhang Z DU Source Type: research
