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Use of TEG/Platelet Mapping to Dose-Adjust Platelet Inhibitors in Children Supported with the Berlin EXCOR: In Search of a Correlation
There is uncertain correlation between doses of aspirin (ASA), dipyridamole (DPM) and clopidogrel (CLP) and the absolute % inhibition as measured by Platelet Mapping, a platelet function test that accompanies Thromboelastography (TEG). This is particularly relevant for children supported with the Berlin EXCOR pediatric ventricular assist device (VAD), as the TEG/PM is currently used to adjust their antiplatelet medications but the stroke rate remains unacceptably high. We sought to determine whether there was better correlation between medication doses and the relative change from baseline in the % inhibition.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: L.J. May, X. Liu, C. Sherwin, L. Yang, J. Zhender, J. Lee, S. Chen, D.N. Rosenthal, C.S. Almond Source Type: research

Thromboelastography/Platelet Mapping® and Aspirin: Is There Evidence of a Meaningful Dose-Response Relationship in Children Supported With the Berlin Heart EXCOR Ventricular Assist Device?
Thromboelastography with Platelet Mapping® (TEG/PM) is widely used to adjust the dose of Aspirin (ASA) for children supported with the Berlin Heart EXCOR Pediatric Ventricular Assist Device (VAD). The use of TEG/PM is controversial in part because stroke remains a common occurrence and TEG/PM has never been validated for this purpose. We sought to determine whether there is a meaningful correlation between the dose of ASA and the TEG/PM ‘percent arachadonic acid (%AA) inhibition’ value in children supported with the EXCOR.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: L.J. May, C. Lo, T.M. Tesoro, J.L. Zehnder, S. Chen, J. Lee, M. Desai, D.B. McElhinney, D.N. Rosenthal, K. Maeda, C.S. Almond Source Type: research

Left Ventricular Assist Devices vs. the Total Artificial Heart: Which Causes More Cerebrovascular Accidents?
More recently, the continuous flow left ventricular assist devices (LVADs) have been more commonly used in patients (pts) with severe left heart failure. However, these devices also have risk for strokes, both ischemic and hemorrhagic. The Total Artificial Heart (TAH) has also been used in patients with biventricular heart failure at our single institution. Both continuous flow LVADs and TAH patients are systemically anti-coagulated with warfarin and aspirin. We sought to compare stroke rates between the LVAD patients and TAH pts.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: C. Runyan, F. Arabia, L. Czer, M. Kittleson, E. Passano, F. Liou, J. Yabuno, H. Henry, D.H. Chang, J. Kobashigawa, J. Moriguchi Source Type: research