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Drug: Morphine
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Total 5155 results found since Jan 2013.
Acupuncture and laserpuncture as a therapeutic approach for nociception and inflammation: An experimental study in mice
This study aims to evaluate the effect of acupuncture and laserpuncture on nociception and inflammation in mice compared to the effects of morphine and dexamethasone. 140 male Swiss mice were used. Treatment with acupuncture and laserpuncture were performed at the acupoints LI11, ST36, GB34, and BL60 in mice. To evaluate the effect of acupuncture and laserpuncture on nociception, the hot plate test and intraplantar formalin injection were used. The effect of acupuncture and laserpuncture on the inflammation was evaluated through carrageenan-induced paw edema. Thermographic analysis was also applied to evaluate the anti-inf...
Source: An Acad Bras Cienc - July 19, 2023 Category: Science Authors: Iara A Coelho Murilo Luiz Cerutti Gisele Arruda Scheila I Kraus Jhenifer K Lorbi éski Regina C élia DE Souza M ário Pansini Caroline Valente Source Type: research
Postoperative analgesia for upper gastrointestinal surgery: a retrospective cohort analysis
CONCLUSIONS: We found that thoracic epidural analgesia was superior to intrathecal morphine, and intrathecal morphine was superior to non-neuraxial analgesia, in terms of reduced postoperative morphine requirements and the probability of adequate pain control in patients who underwent upper gastrointestinal surgery. However, the benefits of thoracic epidural analgesia and intrathecal morphine were not sustained across all time periods regarding control of pain. The study is limited by its retrospective design, heterogenous group of upper gastrointestinal surgeries and confounding by indication.PMID:37464387 | DOI:10.1186/s13741-023-00324-0
Source: Cancer Control - July 18, 2023 Category: Cancer & Oncology Authors: Katrina P Pirie Andy Wang Joanna Yu Bao Teng Matthew A Doane Paul S Myles Bernhard Riedel Source Type: research
Tumor necrosis factor- α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways
Neuropharmacology. 2023 Jul 12:109667. doi: 10.1016/j.neuropharm.2023.109667. Online ahead of print.ABSTRACTChronic morphine tolerance is a repulsive barrier to the clinical treatment of pain. Whereas the underlying molecular mechanisms of morphine tolerance remain unknown. Here, we proposed that tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is an essential control point regarding the progression of chronic morphine tolerance. We found that TIPE2 levels in the lumbar spinal cord were significantly downregulated in the morphine tolerance mouse model. Specifically, decreased TIPE2 by morphine tolerance was primar...
Source: Neuropharmacology - July 14, 2023 Category: Drugs & Pharmacology Authors: Zhong Yang Feifei Zhang Mannan Abdul Jinhong Jiang Yanqiang Li Yeqi Li Cui Yin Yanhong Xing Su Liu Chen Lu Source Type: research
Rectus sheath catheters reduce opiate use in pancreaticoduodenectomy: a pre- and postintervention cohort study
CONCLUSION: The use of RSCs was associated with significant reductions in postoperative opiate consumption. Given the ease of placement and management, with minimal complications, RSCs should be incorporated into a course of postoperative multimodal analgesia. A large scale randomized controlled trial should be conducted to further investigate these findings.PMID:37442583 | DOI:10.1503/cjs.006922
Source: Canadian Journal of Surgery - July 13, 2023 Category: Surgery Authors: Patrick L C Tapley Martin Van der Vyver Natalie G Coburn Julie Hallet Calvin Law Rachel Roke Paul J Karanicolas Source Type: research
Efficacy of combining intravenous and topical dexamethasone against postoperative pain and function recovery after total knee arthroplasty: A prospective, double-blind, randomized controlled trial
CONCLUSION: Compared with placebo, the combination of intravenous and topical dexamethasone can reduce pain, swelling, and inflammation after TKA, it also can improve functional recovery and reduce the incidence of postoperative nausea and vomiting.PMID:37437069 | DOI:10.1177/10225536231189782
Source: Journal of Orthopaedic Surgery - July 12, 2023 Category: Orthopaedics Authors: Changjun Wu Defa Luo Yu Zhu Qingyuan Zhao Jian Wang Yunlei Dai Source Type: research
