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Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease
CONCLUSIONS: These results demonstrate endothelial dysfunction in one out of three young women with FHA. FHA may be a contributor to preclinical CVD, and it is not explained by hypoestrogenemia alone.PMID:37610989 | DOI:10.1210/clinem/dgad498
Source: The Journal of Clinical Endocrinology and Metabolism - August 23, 2023 Category: Endocrinology Authors: Chrisandra L Shufelt Mariam Saadedine Galen Cook-Wiens Margareta D Pisarska JoAnn E Manson Sarah L Berga Moshe Arditi Prediman K Shah C Noel Bairey Merz Source Type: research

Multicenter Analysis of Cardiometabolic-Related Diagnoses in Transgender and Gender Diverse Youth: a PEDSnet study
CONCLUSIONS: TGDY have increased odds of overweight/obesity compared to matched controls. Screening and tailored weight management, sensitive to the needs of TGDY, are needed.PMID:35945152 | DOI:10.1210/clinem/dgac469
Source: The Journal of Clinical Endocrinology and Metabolism - August 9, 2022 Category: Endocrinology Authors: Anna Valentine Shanlee Davis Anna Furniss Nadia Dowshen Anne E Kazak Christopher Lewis Danielle F Loeb Leena Nahata Laura Pyle Lisa M Schilling Gina M Sequeira Natalie Nokoff Source Type: research

DrugWAS: Drug-wide association studies for COVID-19 drug repurposing
In conclusion, this cohort study leveraged EHR data to identify a list of drugs that could be repurposed to improve COVID-19 outcomes. Further randomized clinical trials are needed to investigate the efficacy of the proposed drugs.PMID:34314511 | DOI:10.1002/cpt.2376
Source: Clinical Pharmacology and Therapeutics - July 27, 2021 Category: Drugs & Pharmacology Authors: Cosmin A Bejan Katherine N Cahill Patrick J Staso Leena Choi Josh F Peterson Elizabeth J Phillips Source Type: research

Fight Aging! Newsletter, October 14th 2019
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the ...
Source: Fight Aging! - October 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs