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Specialty: Chemistry
Drug: Metformin
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Total 170 results found since Jan 2013.
Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea
Chemosphere. 2023 Sep 7:140070. doi: 10.1016/j.chemosphere.2023.140070. Online ahead of print.ABSTRACTThe antidiabetic drug metformin (MET) and its metabolite guanylurea (GUA) have been frequently and ubiquitously detected in surface water. Consequently, there has been a consistent rise in studying the toxicity of MET and GUA in fish over the past decade. Nonetheless, it is noteworthy that no study has assessed the harmful effects both compounds might trigger on fish blood and organs after chronic exposure. Taking into consideration the data above, our research strived to accomplish two primary objectives: Firstly, to asse...
Source: Chemosphere - September 9, 2023 Category: Chemistry Authors: Gustavo Axel Elizalde-Vel ázquez Selene Elizabeth Herrera-V ázquez Leobardo Manuel G ómez-Oliván Sandra Garc ía-Medina Source Type: research
The metformin immunoregulatory actions in tumor suppression and normal tissues protection
Curr Med Chem. 2023 Jul 3. doi: 10.2174/0929867331666230703143907. Online ahead of print.ABSTRACTThe immune system is the key player in a wide range of responses in normal tissues and tumors to anticancer therapy. Inflammatory and fibrotic responses in normal tissues are the main limitations of chemotherapy, radiotherapy, and also some newer anticancer drugs such as immune checkpoint inhibitors (ICIs). Immune system responses within solid tumors including anti-tumor and tumor-promoting responses can suppress or help tumor growth. Thus, modulation of immune cells and their secretions such as cytokines, growth factors and ep...
Source: Current Medicinal Chemistry - July 5, 2023 Category: Chemistry Authors: Jitendra Gupta Abduladheem Turki Jalil Zahraa Hamzaa Abd Alzahraa Zafar Aminov Fahad Alsaikhan Andr és Alexis Ramírez-Coronel Pushpamala Ramaiah Masoud Najafi Source Type: research
Electrochemical oxidation technique to pharmaceutical pollutants removal
Chemosphere. 2023 Jun 28:139373. doi: 10.1016/j.chemosphere.2023.139373. Online ahead of print.ABSTRACTHuman progress in medical science and drug production has improved the growth process and increased human lifespan. Most of the drugs used are to control or prevent common human diseases. These drugs can be produced in different ways such as synthetic, chemical, biological, etc. On the other hand, pharmaceutical companies have a large volume of pharmaceutical effluents and wastewater that enters the environment and harms nature and human life. The main problems of entering the pharmaceutical effluent into the environmenta...
Source: Chemosphere - June 30, 2023 Category: Chemistry Authors: Chunying Wu Ji Ge Feng Gu Lu Bai Source Type: research
Photocatalytic and Electrochemical Borylation and Silylation Reactions
Chem Rec. 2023 Jun 26:e202300172. doi: 10.1002/tcr.202300172. Online ahead of print.ABSTRACTDue to their high versatility borylated and silylated compounds are inevitable synthons for organic chemists. To escape the classical hydroboration/hydrosilylation paradigm, chemists turned their attention to more modern and green methods such as photoredox chemistry and electrosynthesis. This account focuses on novel methods for the generation of boryl and silyl radicals to forge C-B and C-Si bonds from our group.PMID:37358334 | DOI:10.1002/tcr.202300172
Source: Chemical Record - June 26, 2023 Category: Chemistry Authors: Tony Biremond Margaux Riomet Philippe Jubault Thomas Poisson Source Type: research
Isolation and antihyperglycemic effects of garcibractinols A-H, intricate polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia bracteata
Bioorg Chem. 2023 Jun 5;138:106651. doi: 10.1016/j.bioorg.2023.106651. Online ahead of print.ABSTRACTEight previously undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) were isolated from the fruits of Garcinia bracteata and named garcibractinols A-H. Garcibractinols A-F (compounds 1-6) were bicyclic polyprenylated acylphloroglucinols (BPAPs) sharing a rare bicyclo[4.3.1]decane core. On the other hand, garcibractinols G and H (compounds 7 and 8) shared an unprecedented BPAP skeleton bearing a 9-oxabicyclo[6.2.1]undecane core. The structures andabsolute configurations of compounds 1-8 were determined by spect...
Source: Bioorganic Chemistry - June 10, 2023 Category: Chemistry Authors: Xueni Li Qingqing Li Jing Xu Shuang Yang Xin Hu Zhengyang Lu Gui Mei Yu Chen Zhinan Mei Guangzhong Yang Source Type: research
