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Drug: Metformin
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Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis
Pharmacol Rep. 2023 Apr 24. doi: 10.1007/s43440-023-00469-1. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a metabolic disease that activates several molecular pathways involved in neurodegenerative disorders. Metformin, an anti-hyperglycemic drug used for treating DM, has the potential to exert a significant neuroprotective role against the detrimental effects of DM. This review discusses recent clinical and laboratory studies investigating the neuroprotective properties of metformin against DM-induced neurodegeneration and the roles of various molecular pathways, including mitochondrial dysfunction, oxidative s...
Source: Pharmacological Reports - April 24, 2023 Category: Drugs & Pharmacology Authors: Fatemeh Karami Hamidreza Jamaati Natalie Coleman-Fuller Maryam Shokrian Zeini A Wallace Hayes Mina Gholami Mahsa Salehirad Mohammad Darabi Majid Motaghinejad Source Type: research
Efficacy and Safety of Triple Therapy with SGLT-2 Inhibitor, DPP-4 Inhibitor, and Metformin in Type 2 Diabetes: A Meta-Analysis
CONCLUSIONS: Based on current evidence, triple therapy was found to significantly improve blood glucose, body weight, and blood pressure when compared to dual therapy. Safety indicators did not show significant differences, except for an increased risk of genital tract infection.PMID:37171944
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Mengdi Li Sining Wang Xiaoli Wang Source Type: research
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Efficacy and Safety of Triple Therapy with SGLT-2 Inhibitor, DPP-4 Inhibitor, and Metformin in Type 2 Diabetes: A Meta-Analysis
CONCLUSIONS: Based on current evidence, triple therapy was found to significantly improve blood glucose, body weight, and blood pressure when compared to dual therapy. Safety indicators did not show significant differences, except for an increased risk of genital tract infection.PMID:37171944
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Mengdi Li Sining Wang Xiaoli Wang Source Type: research
