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Infectious Disease: Malaria
Drug: Metformin
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Total 32 results found since Jan 2013.
A novel pharmacological mechanism of anti-cancer drugs that induce pyroptosis
Inflammopharmacology. 2023 Mar 3. doi: 10.1007/s10787-023-01148-6. Online ahead of print.ABSTRACTPyroptosis is an inflammasome-induced lytic form of programmed cell death, and its main effect involves the release of inflammatory mediators when a cell dies, resulting in an inflammatory response in the body. The key to pyroptosis is the cleavage of GSDMD or other gasdermin families. Some drugs can cause cleavage GSDMD or other gasdermin members cause pyroptosis and suppress cancer growth and development. This review explores several drugs that may induce pyroptosis, thereby contributing to tumor treatment. Pyroptosis-inducin...
Source: Cancer Control - March 3, 2023 Category: Cancer & Oncology Authors: Haohao Guo Ziyang Wang Runsheng Ma Xin Chen Hongqiang Li Yifeng Tang Gongbo Du Yifei Zhang Detao Yin Source Type: research
An adjuvant effect of Metformin as an anti-fibrotic agent when administered with the anti-schistosomal Praziquantel in Schistosoma mansoni infected mice
This study aimed to evaluate the role of Met as anti-schistosomal and anti-fibrotic agents alone or in combination with PZQ treatment. Forty male CD1 mice were divided into four groups (n=10 mice) as following; the first group (Gp1) was served as a negative control. Gp2, Gp3, Gp4, and Gp5 were infected with (60-80) S. mansoni cercariae. After a month of infection, Gp3 was administered orally with PZQ (500 mg/Kg) for 2 consecutive days. Gp4 was administered orally with Met (150 mg/Kg) for 15 consecutive days, and Gp5 was orally administered with PZQ followed by Met for 15 consecutive days at the same doses as in Gp 3 and 4....
Source: Tropical Biomedicine - June 26, 2021 Category: Tropical Medicine Authors: W M Salama S A El-Naggar S F Harras K S El-Said Source Type: research
