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Approach to the Patient with Youth-Onset Type 2 Diabetes
J Clin Endocrinol Metab. 2023 Aug 16:dgad482. doi: 10.1210/clinem/dgad482. Online ahead of print.ABSTRACTYouth-onset type 2 diabetes is a growing epidemic with a rising incidence worldwide. Although the pathogenesis and diagnosis of youth-onset type 2 diabetes are similar to adult-onset type 2 diabetes, youth-onset type 2 diabetes is unique, with greater insulin resistance, insulin hypersecretion, and faster progression of pancreatic beta cell function decline. Individuals with youth-onset type 2 diabetes also develop complications at higher rates within short periods of time compared to adults with type 2 diabetes or yout...
Source: The Journal of Clinical Endocrinology and Metabolism - August 16, 2023 Category: Endocrinology Authors: Talia A Hitt Tamara S Hannon Sheela N Magge Source Type: research

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: American Journal of Physiology. Renal Physiology - July 27, 2023 Category: Physiology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research

An insight into the combat strategies for the treatment of type 2 diabetes mellitus
Mini Rev Med Chem. 2023 May 17. doi: 10.2174/1389557523666230517113936. Online ahead of print.ABSTRACTDiabetes is a chronic, and metabolic disorder that has gained epidemic proportions in the past few decades creating a threat throughout the globe. It is characterized by increased glucose levels that may be due to immune-mediated disorders (T1DM), insulin resistance or inability to produce sufficient insulin by β-pancreatic cells (T2DM), gestational, or an increasingly sedentary lifestyle. The progression of the disease is marked by several pathological changes in the body like nephropathy, retinopathy, and various cardio...
Source: Mini Reviews in Medicinal Chemistry - May 18, 2023 Category: Chemistry Authors: Gita Chawla Tathagata Pradhan Ojasvi Gupta Source Type: research

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