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Addressing Post-Treatment Selection Bias in Comparative Effectiveness Research, Using Real-world Data and Simulation
Am J Epidemiol. 2021 Oct 6:kwab242. doi: 10.1093/aje/kwab242. Online ahead of print.ABSTRACTTo examine methodologies that address imbalanced treatment switching and censoring, six different analytic approaches were evaluated under a comparative effectiveness framework: intention-to-treat, as-treated, intention-to-treat with censor-weighting, as-treated with censor-weighting, time-varying exposure, and time-varying exposure with censor-weighting. Marginal structural models were employed to address time-varying exposure, confounding, and possibly informative censoring in an administrative dataset of adult patients who were h...
Source: Am J Epidemiol - October 6, 2021 Category: Epidemiology Authors: Nicholas Belviso Yichi Zhang Herbert D Aronow Richard Wyss Marilyn Barbour Stephen Kogut Oluwadolapo D Lawal Siyan Zhan Prabhani Kuruppumullage Don Xuerong Wen Source Type: research

Comparison of Net Clinical Benefit Between Clopidogrel and Ticagrelor Following Percutaneous Coronary Intervention in Patients in China With Acute Coronary Syndrome
CONCLUSION: In Chinese ACS patients who underwent PCI with second-generation DESs, outpatient use of clopidogrel dual antiplatelet therapy (DAPT) was associated with reduction in NACCE and bleeding.PMID:34904209 | DOI:10.1007/s12325-021-01907-3
Source: Adv Data - December 14, 2021 Category: Epidemiology Authors: Dandan Li Yang Sun Xiaoran Ye Lanting Li Yundai Chen Daowen Wang Source Type: research