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Drug: Ciprofloxacin

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Total 6774 results found since Jan 2013.

The search of potential inhibitors of the AcrAB-TolC system of multidrug-resistant Escherichia coli: an in silico approach.
Abstract The number of infections caused by multidrug antibiotic resistance (MDR) species is increasing globally. The efflux pump system, AcrAB-TolC, confers Escherichia coli resistance to many antibiotics and results in poor treatment outcomes. Different rational drug design techniques were employed to search for a safe and effective AcrAB-TolC system inhibitor. Ligand docking was performed to analyze the binding of different ArcB substrates and/or inhibitors in the different AcrAB crystal structure binding sites. The validated docking site using the established docking preferences was used to perform virtual hig...
Source: Applied Microbiology and Biotechnology - June 16, 2019 Category: Microbiology Authors: Abdel-Halim H, Al Dajani A, Abdelhalim A, Abdelmalek S Tags: Appl Microbiol Biotechnol Source Type: research

Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.
Abstract A series of 1,2,4-triazole-based compounds was designed as potential antibacterial agents using molecular hybridization approach. The target compounds (23-44) were synthesized by Mannich reaction of 1,2,4-triazole-3-thione derivatives with ciprofloxacin (CPX) and formaldehyde. Their potent antibacterial effect on Gram-positive bacteria was accompanied by similarly strong activity against Gram-negative strains. The toxicity of the CPX-triazole hybrids for bacterial cells was even up to 18930 times higher than the toxicity for human cells. The results of enzymatic studies showed that the antibacterial activ...
Source: European Journal of Medicinal Chemistry - April 29, 2015 Category: Chemistry Authors: Plech T, Kaproń B, Paneth A, Kosikowska U, Malm A, Strzelczyk A, Stączek P, Świątek Ł, Rajtar B, Polz-Dacewicz M Tags: Eur J Med Chem Source Type: research

Topological pattern for the search of new active drugs against methicillin resistant Staphylococcus aureus.
Abstract Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it. This model was appl...
Source: European Journal of Medicinal Chemistry - July 8, 2017 Category: Chemistry Authors: Bueso-Bordils JI, Perez-Gracia MT, Suay-Garcia B, Duart MJ, Martin Algarra RV, Lahuerta Zamora L, Anton-Fos GM, Aleman Lopez PA Tags: Eur J Med Chem Source Type: research

From quinoline to quinazoline-based S. aureus NorA efflux pump inhibitors by coupling focused scaffold hopping approach and pharmacophore search
ChemMedChem. 2021 May 25. doi: 10.1002/cmdc.202100282. Online ahead of print.ABSTRACTAntibiotic resistance breakers, such as efflux pump inhibitors (EPIs), represent a powerful alternative to the development of new antimicrobials. Recently, by using previously described EPIs, we developed pharmacophore models able to identify inhibitors of NorA, the most studied efflux pump of the Staphylococcus aureus. Herein, we reported a pharmacophore-based virtual screening of a library of new potential NorA EPIs generated by an in-silico scaffold hopping approach of the quinoline core. After chemical synthesis and biological evaluati...
Source: ChemMedChem - May 25, 2021 Category: Chemistry Authors: Nicholas Cedraro Rolando Cannalire Andrea Astolfi Gianmarco Mangiaterra Tommaso Felicetti Salvatore Vaiasicca Giada Cernicchi Serena Massari Giuseppe Manfroni Oriana Tabarrini Violetta Cecchetti Maria Letizia Barreca Francesca Biavasco Stefano Sabatini Source Type: research

Search for a Shared Genetic or Biochemical Basis for Biofilm Tolerance to Antibiotics across Bacterial Species
Antimicrob Agents Chemother. 2022 Mar 10:e0002122. doi: 10.1128/aac.00021-22. Online ahead of print.ABSTRACTIs there a universal genetically programmed defense providing tolerance to antibiotics when bacteria grow as biofilms? A comparison between biofilms of three different bacterial species by transcriptomic and metabolomic approaches uncovered no evidence of one. Single-species biofilms of three bacterial species (Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii) were grown in vitro for 3 days and then challenged with respective antibiotics (ciprofloxacin, daptomycin, and tigecycline) for an ad...
Source: Antimicrobial Agents and Chemotherapy - March 10, 2022 Category: Microbiology Authors: Philip S Stewart Kerry S Williamson Laura Boegli Timothy Hamerly Ben White Liam Scott Xiao Hu Brendan M Mumey Michael J Franklin Brian Bothner Francisco G Vital-Lopez Anders Wallqvist Garth A James Source Type: research

Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Development
This invention comprises monoclonal antibodies, proteins, and related nucleic acid coding sequences that identify all or part of the antigenic anthrose oligosaccharide ofBacillus anthracis, the causative agent of anthrax toxicity in humans. It is imperative to identify virulentB. anthracis with speed and specificity, however there presently is substantial difficulty in early-stage recognition and diagnosis of anthrax inhalation. Improved diagnostic assays that can reliably identify anthrax exposure in its earliest stages and distinguish anthrax from other flu-like illnesses are sorely needed.CDC and collaborative researche...
Source: NIH OTT Licensing Opportunities - January 28, 2014 Category: Research Authors: ajoyprabhu3 Source Type: research

Aradigm lands NIH grant for inhaled, liposomal products
Aradigm Corp. (NSDQ:ARDM) said today that the National Institute of Allergy and Infectious Diseases and the NIH awarded the company a grant to study the treatment of pulmonary non-tuberculous mycobacteria infections with Aradigm’s inhaled liposomal ciprofloxacin products, Linhaliq and Lipoquin. The two-year grant is worth approximately $972,000, according to the Hayward, Calif.-based company. Get the full story at our sister site, Drug Delivery Business News. The post Aradigm lands NIH grant for inhaled, liposomal products appeared first on MassDevice.
Source: Mass Device - August 15, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Funding Roundup Pharmaceuticals Respiratory Wall Street Beat Aradigm Corp. Source Type: news

Synergistic Use of Exo VII Inhibitors And Quinolone Antibiotics For Treating Bacterial Infection
Topoisomerase poisons, such as quinolone antibiotics, are widely used as anticancer drugs and antibiotics. Quinolone antibiotics act by trapping prokaryotic type IIA topoisomerases (DNA gyrase and TOPO IV), resulting in irreversible topoisomerase cleavage complexes. However, current U.S. Food and Drug Administration (FDA) guidance reserves the use of quinolones for the most serious bacterial infections due to their associated side effects and to limit the occurrence of drug-resistant bacterial strains. Resistance to available antibiotics in pathogenic bacteria is a global challenge as the number of drug-resistant strains i...
Source: NIH OTT Licensing Opportunities - May 12, 2021 Category: Research Authors: ott-admin Source Type: research

Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review.
Abstract This systematic review aimed to evaluate whether alternative materials to conventional triple antibiotic paste (TAP - metronidazole, ciprofloxacin, and minocycline) and grey mineral trioxide aggregate (GMTA) could avoid tooth discoloration in teeth submitted to Regenerative Endodontic Procedure (REP). It was also investigated if dental bleaching is able to reverse the color of darkened teeth due to REP. The search was conducted in four databases (Medline via PubMed, Scopus, ISI Web of Science and BVS - Virtual health library), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyse...
Source: Braz Dent J - September 1, 2018 Category: Dentistry Authors: Santos LGPD, Chisini LA, Springmann CG, Souza BDM, Pappen FG, Demarco FF, Felippe MCS, Felippe WT Tags: Braz Dent J Source Type: research

Anaerobic biodegradation of pharmaceutical compounds: New insights into the pharmaceutical-degrading bacteria
Publication date: 5 September 2018 Source:Journal of Hazardous Materials, Volume 357 Author(s): Mónica Martins, Sandra Sanches, Inês A.C. Pereira Antibiotics and hormones are among the most concerning trace contaminants in the environment. Therefore, the present work aimed to identify anaerobic microorganisms with the ability to remove pharmaceutical products (PhPs) belonging to these two classes (ciprofloxacin, 17β-estradiol and sulfamethoxazole) under different anaerobic conditions, and to elucidate the bio-removal mechanisms involved. Ciprofloxacin was efficiently biodegraded under both nitrate- and sulfate-reducing...
Source: Journal of Hazardous Materials - June 15, 2018 Category: Environmental Health Source Type: research