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Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research

Interventions for treating anxiety after stroke.
CONCLUSIONS: Evidence is insufficient to guide the treatment of anxiety after stroke. Further well-conducted randomised controlled trials (using placebo or attention controls) are required to assess pharmacological agents and psychological therapies. PMID: 28535332 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 23, 2017 Category: General Medicine Authors: Knapp P, Campbell Burton CA, Holmes J, Murray J, Gillespie D, Lightbody CE, Watkins CL, Chun HY, Lewis SR Tags: Cochrane Database Syst Rev Source Type: research

EuroHYP‐1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke
DiscussionWith 750 patients per intervention group, this trial has 90% power to detect 7% absolute improvement at the 5% significance level. The full trial protocol is available at http://www.eurohyp1.eu. ClinicalTrials.gov Identifier: NCT01833312.
Source: International Journal of Stroke - May 15, 2014 Category: Neurology Authors: H. Bart Worp, Malcolm R. Macleod, Philip M. W. Bath, Jacques Demotes, Isabelle Durand‐Zaleski, Bernd Gebhardt, Christian Gluud, Rainer Kollmar, Derk W. Krieger, Kennedy R. Lees, Carlos Molina, Joan Montaner, Risto O. Roine, Jesper Petersson, Dimitre Sta Tags: Protocols Source Type: research