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Drug: Methotrexate
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Is Methotrexate Ototoxic? Investigating the Ototoxic Late Effects of Pediatric Cancer Treatment
CONCLUSIONS: The results from this study suggest that children who receive therapies not clinically established as ototoxic (i.e., methotrexate) may still be at a high risk of developing long-term hearing loss as a late effect. Due to the high incidence rate of hearing loss among patients with pediatric cancer, we recommend that audiologists be part of the late-effects care team. This study also demonstrates that patients with pediatric cancer treated with methotrexate should receive routine long-term auditory monitoring as part of their standard of care to detect and manage hearing loss early, minimizing adverse outcomes....
Source: American Journal of Audiology - August 2, 2023 Category: Audiology Authors: Brittney Moore Gabrielle Sheets Jordan Doss Ayesha Umrigar Michael Norman Zhide Fang Pinki Prasad Amanda Musso Sloane Clay Fern Tsien Source Type: research
A fatal interstitial lung disease in an anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody negative patient with juvenile dermatomyositis
CONCLUSIONS: Juvenile dermatomyositis patients should be carefully monitored for the development of interstitial lung disease. Rapidly progressive interstitial lung disease with a high mortality may develop shortly after diagnosis, even if the anti-melanoma differentiation associated gene 5 antibody is negative.PMID:34738372 | DOI:10.24953/turkjped.2021.05.018
Source: The Turkish Journal of Pediatrics - November 5, 2021 Category: Pediatrics Authors: Osman Ye şilbaş Mehmet Y ıldız Can Y ılmaz Yozgat Irmak Tahao ğlu Hakan Yazan Erkan Çakır Amra Adrovic Sezgin Şahin Kenan Barut Özgür Kasapçopur Source Type: research
