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Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in < em > db/db < /em > mice
This study aimed to determine the effect of loss of endothelial GR on organ fibrosis in the db/db model. Db/Db mice lacking endothelial GR showed more severe fibrosis in multiple organs compared to endothelial GR-replete db/db mice. Organ fibrosis could be substantially improved either through administration of a Wnt inhibitor or metformin. IL-6 is a key cytokine driving the fibrosis phenotype and is mechanistically linked to Wnt signaling. The db/db model is an important tool to study mechanisms of fibrosis and its phenotype in the absence of endothelial GR highlights the synergistic effects of Wnt signaling and inflammat...
Source: Am J Physiol Renal P... - August 17, 2023 Category: Urology & Nephrology Authors: Swayam Prakash Srivastava Julie E Goodwin Source Type: research

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: Am J Physiol Renal P... - July 27, 2023 Category: Urology & Nephrology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research

The Association of Background Medications on Initial eGFR Change and Kidney Outcomes in Diabetic Patients Receiving SGLT2 Inhibitor
CONCLUSIONS: Several background medications were associated with the initial eGFR dip following SGLT2i initiation. Most drugs were not associated with long-term composite kidney outcomes among patients treated with SGLT2i, except for renin-angiotensin system inhibitor associated with favorable outcomes and loop diuretics associated with worse composite kidney outcomes.PMID:36999982 | DOI:10.2215/CJN.0000000000000159
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 31, 2023 Category: Urology & Nephrology Authors: Yi-Hsin Chan Tze-Fan Chao Shao-Wei Chen Yi-Wei Kao Chien-Ying Huang Pao-Hsien Chu Source Type: research

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