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Drug: Temodar
Procedure: Gastroschisis Repair
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Total 170 results found since Jan 2013.
Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O < sup > 6 < /sup > -methylguanine-DNA methyltransferase gene in glioblastoma
CONCLUSION: This study provides novel mechanisms to understand methylation in GBM and identifies some biomarkers for the prognosis of two different GBM types, MGMT promoter unmethylated or methylated GBM, by using metabolomics and proteomics analyses.PMID:37641495 | DOI:10.1111/cns.14415
Source: CNS Neuroscience and Therapeutics - August 29, 2023 Category: Neuroscience Authors: Xi Chen Jinli Sun Yukui Li Weichao Jiang Zhangyu Li Jianyao Mao Liwei Zhou Sifang Chen Guowei Tan Source Type: research
EZH2-regulated PARP 1 Expression is a Likely Mechanism for the Chemoresistance of Gliomas to Temozolomide
CONCLUSION: EZH2 PARP 1 signaling axis is possibly responsible for the chemoresistance of gliomas to TMZ. Simultaneously inhibiting these two genes may improve the outcome of TMZ chemotherapy.PMID:37594167 | DOI:10.2174/1568009623666230818151830
Source: Current Cancer Drug Targets - August 18, 2023 Category: Cancer & Oncology Authors: Qiang Liang Bing Wang Chenran Zhang Chaoli Song Junyu Wang Wei Sun Lei Jiang Jing Lin Source Type: research
Preclinical efficacy of LP-184, a tumor site activated synthetic lethal therapeutic, in glioblastoma
CONCLUSIONS: These results establish LP-184 as a promising chemotherapeutic for GBM with enhanced efficacy in intrinsic or spironolactone-induced TC-NER deficient tumors.PMID:37494541 | DOI:10.1158/1078-0432.CCR-23-0673
Source: Clinical Cancer Research - July 26, 2023 Category: Cancer & Oncology Authors: Bachchu Lal Aditya Kulkarni Joseph McDermott Rana Rais Jesse Alt Ying Wu Hernando Lopez-Bertoni Sophie Sall Umesh Kathad Jianli Zhou Barbara S Slusher Kishor Bhatia John Laterra Source Type: research
Quantitative profiling of genes associated with cancer pathways in brain tumors
CONCLUSION: Based on the obtained data, we can conclude that individual diagnoses differ in transcriptomic profile. An individual molecular approach is therefore necessary in order to provide comprehensive and targeted therapy on multiple metabolic pathways in the diagnosis of brain tumors.PMID:37353350 | DOI:10.48095/ccko2023224
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Z Majer číková K Dibdiakov á M Galanda T Galanda R Richterov á B Kolarovszki P Ra čay J Hatok Source Type: research
