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Combinatorial Effect of Temozolomide and Naringenin in Human Glioblastoma Multiforme Cell Lines
Nutr Cancer. 2021 Aug 25:1-8. doi: 10.1080/01635581.2021.1952438. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is a grade IV, lethal, and the most common type of brain tumor. GBM can acquire resistance to temozolomide (TMZ) recommended for its treatment. Naringenin (NAG), a flavonoid generally found in grapefruit, has antioxidant, anti-proliferative, and anti-inflammatory properties. It has been reported that phytochemicals can reduce resistance and improve the efficacy of a chemo-resistant drug. The combinatorial effect of TMZ and NAG on cell proliferation was evaluated using 3-4,5-dimethylthiazol-2-yl-2,5-...
Source: Nutrition and Cancer - August 25, 2021 Category: Cancer & Oncology Authors: Megha Gautam Reema Gabrani Source Type: research

Synergistic Effect of Gefitinib and Temozolomide on U87MG Glioblastoma Angiogenesis
This study indicates synergistic effects of GFI plus TMZ against glioma are mediated by the potentiated anti-angiogenesis. Therefore, it can be considered as a promising plan for future studies.PMID:34296963 | DOI:10.1080/01635581.2021.1952441
Source: Nutrition and Cancer - July 23, 2021 Category: Cancer & Oncology Authors: Afshin Karami Maryam Hossienpour Ehsan Mohammadi Noori Mehdi Rahpyma Khadijeh Najafi Amir Kiani Source Type: research

Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats
In conclusions, the inhibitory effect of caffeine on TMZ-treated glioma might be associated with increasing expressions of autophagy- and apoptosis-related genes.PMID:34060393 | DOI:10.1080/01635581.2021.1931361
Source: Nutrition and Cancer - June 1, 2021 Category: Cancer & Oncology Authors: Jin-Cherng Chen Juen-Haur Hwang Source Type: research

Hematological Side Effects of Immune Checkpoint Inhibitors: The Example of Immune-Related Thrombocytopenia
Conclusion Hem-irAEs are potentially life-threatening complications of ICIs that require a high level of clinical suspicion. Ir-TCP is amongst the most frequently reported hem-irAEs. Due to its low incidence and the lack of specific diagnostic criteria, ir-TCP may be underdiagnosed and possibly underreported. The diagnosis is based on exclusion of other causes of TCP together with clinical features that suggest an immune event such as the refractoriness to platelet transfusions and response to corticosteroids. During clinical development, a systematic analysis of ir-TCP cases at clinical study and program level is of outm...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research