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Specialty: Drugs & Pharmacology
Drug: Taxotere
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Total 169 results found since Jan 2013.
Targeted Therapies for Previously "Undruggable" KRAS-Mutated Non-Small Cell Lung Cancer: A Review of Sotorasib and Adagrasib
CONCLUSION: Sotorasib and adagrasib demonstrated promising outcomes in targeting the constitutively active KRAS G12C oncogenic driver, underscoring the need for further research to optimize their therapeutic application in this high-risk population.PMID:37700573 | DOI:10.1177/10600280231197459
Source: The Annals of Pharmacotherapy - September 13, 2023 Category: Drugs & Pharmacology Authors: Natalie Mausey Zachery Halford Source Type: research
Real-World Progression-Free Survival as an Endpoint in Lung Cancer: Replicating Atezolizumab and Docetaxel Arms of the OAK Trial using real-world data
This study replicated the atezolizumab and docetaxel arms of the OAK trial using RWD and compared progression-free survival (PFS) outcomes derived from abstracted physician's notes in RWD (rwPFS) against PFS outcomes derived from the clinical trial (ctPFS). Atezolizumab and docetaxel arms of the phase III OAK RCT (NCT02008227) were replicated in a US nationwide real-world database using selected OAK inclusion/exclusion criteria and propensity score-based adjustment for baseline prognostic variables. Concordance of outcomes was assessed using Kaplan-Meier (KM) medians and hazard ratios (HRs). The RWD cohorts comprised 133 a...
Source: Clinical Pharmacology and Therapeutics - September 11, 2023 Category: Drugs & Pharmacology Authors: Shivani K Mhatre Robson J M Machado Thanh G N Ton Huong Trinh Julien Mazieres Achim Rittmeyer Michael T Bretscher Source Type: research
Synthesis of Au-Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy
Arch Pharm Res. 2023 Aug 17. doi: 10.1007/s12272-023-01457-y. Online ahead of print.ABSTRACTGreen synthesis strategies have been widely applied for the preparation of versatile nanomaterials. Gold nanospheres with an average size of 6.95 ± 2.25 nm were green synthesized by using a 70% ethanol extract of Korean red ginseng (Panax ginseng Meyer) root as a reducing agent. A seed-mediated synthesis was conducted to prepare Au-Ag bimetallic nanoparticles using gold nanospheres as seeds. Remarkably, Au-Ag bimetallic nanoparticles with an average size of 80.4 ± 11.9 nm were synthesized. Scanning transmission electron microscopy...
Source: Archives of Pharmacal Research - August 17, 2023 Category: Drugs & Pharmacology Authors: Gayeon Lee You Jeong Lee Yeon-Jeong Kim Youmie Park Source Type: research
