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Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Socioeconomic position and prognosis in premenopausal breast cancer: a population-based cohort study in Denmark
CONCLUSIONS: Low SEP in premenopausal women with non-metastatic breast cancer was associated with increased mortality, but not always recurrence. This suggests underdetection of recurrences in certain groups. Poor prognosis in women with low SEP, especially single women, may partly be explained by tamoxifen adherence.PMID:34587961 | DOI:10.1186/s12916-021-02108-z
Source: Clinical Genitourinary Cancer - September 30, 2021 Category: Cancer & Oncology Authors: Cathrine Fonnesbech Hjorth Per Damkier Bent Ejlertsen Timothy Lash Henrik Toft S ørensen Deirdre Cronin-Fenton Source Type: research