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Specialty: Respiratory Medicine
Drug: Proair HFA
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Impaired cardiac and peripheral hemodynamic responses to inhaled β 2 -agonist in cystic fibrosis
Background:
Pulmonary system dysfunction is a hallmark of cystic fibrosis (CF) disease. In addition to impaired cystic fibrosis transmembrane conductance regulator protein, dysfunctional β
2
-adrenergic receptors (β
2
AR) contribute to low airway function in CF. Recent observations suggest CF may also be associated with impaired cardiac function that is demonstrated by attenuated cardiac output (Q), stroke volume (SV), and cardiac power (CP) at both rest and during exercise. However, β
2
AR regulation of cardiac and peripheral vascular tissue, in-vivo, is un...
Source: Respiratory Research - September 5, 2015 Category: Respiratory Medicine Authors: Erik Van ItersonStephen KarpenSarah BakerCourtney WheatleyWayne MorganEric Snyder Source Type: research
