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N-acetylcysteine Treatment Attenuates Hemodialysis Access-related Limb Pathophysiology in Mice with Chronic Kidney Disease
The objective of this study was to determine if treatment with N-acetylcysteine (NAC) could reduce access-related limb dysfunction in mice. Male and female C57BL6J mice were fed an adenine supplemented diet to induce chronic kidney disease prior to surgical creation of an arteriovenous fistula (AVF) in the iliac vascular bundle. AVF creation significantly increased peak aortic and infrarenal vena cava blood flow velocities, but NAC treatment had no significant impact indicating that fistula maturation was not impacted by NAC treatment. Hindlimb muscle and paw perfusion recovery and muscle capillary density in the AVF limb ...
Source: American Journal of Physiology. Renal Physiology - July 13, 2023 Category: Physiology Authors: Kyoungrae Kim Tomas A Cort Eric M Kunz Jack Moerschel Victoria R Palzkill Gengfu Dong Chatick N Moparthy Erik M Anderson Brian Fazzone Kerri A O'Malley Scott T Robinson Scott A Berceli Terence E Ryan Salvatore T Scali Source Type: research

Management of Poisonings and Intoxications
Clin J Am Soc Nephrol. 2023 Jan 13. doi: 10.2215/CJN.0000000000000057. Online ahead of print.ABSTRACTPoisoning occurs after exposure to any of a number of substances, including medicines, which can result in severe toxicity including death. The nephrologist may be involved in poisonings that cause kidney disease and for targeted treatments. The overall approach to the poisoned patient involves the initial acute resuscitation and performing a risk assessment, whereby the exposure is considered in terms of the anticipated severity and in the context of the patient's status and treatments that may be required. Time-critical i...
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 25, 2023 Category: Urology & Nephrology Authors: Marc Ghannoum Darren M Roberts Source Type: research

N-Acetylcysteine: more than preventing contrast-induced nephropathy in uremic patients-focus on the antioxidant and anti-inflammatory properties
Int Urol Nephrol. 2023 Jan 3. doi: 10.1007/s11255-022-03455-3. Online ahead of print.ABSTRACTOxidative stress (OS) has been recognized as a pathophysiologic mechanism underlying the development and progression of chronic kidney disease (CKD). OS, which results from the disturbance of balance among pro-oxidants and antioxidants favoring the pro-oxidants, is present even in early CKD and increases progressively along with deterioration of kidney function to end-stage kidney disease (ESKD). In ESKD, OS is further exacerbated mainly due to dialysis procedures per se and predisposes to increased cardiovascular morbidity and mor...
Source: Atherosclerosis - January 2, 2023 Category: Cardiology Authors: Dainora Cepaityte Konstantinos Leivaditis Garyfallia Varouktsi Athanasios Roumeliotis Stefanos Roumeliotis Vassilios Liakopoulos Source Type: research

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