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Drug: Acetylcysteine
Nutrition: Vitamin C
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Total 44 results found since Jan 2013.
Antioxidants stimulate BACH1-dependent tumor angiogenesis
J Clin Invest. 2023 Aug 31:e169671. doi: 10.1172/JCI169671. Online ahead of print.ABSTRACTLung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs); but growing evidence indicate that transcriptional programs beyond HIFs control tumor angiogenesis. Here we show that the redox-sensitive transcription factor BTB and CNC homology 1 (BACH1) controls the transcription of a broad range of angiogenesis genes. BACH1 is stabilized by lowering reactive oxygen species levels; consequently, angiogenesis gene expression in lung cancer cells, tu...
Source: Clinical Lung Cancer - August 31, 2023 Category: Cancer & Oncology Authors: Ting Wang Yongqiang Dong Zhiqiang Huang Guoqing Zhang Ying Zhao Haidong Yao Jianjiang Hu Elin T üksammel Huan Cai Ning Liang Xiufeng Xu Xijie Yang Sarah Schmidt Xi Qiao Susanne Schlisio Staffan Str ömblad Hong Qian Changtao Jiang Eckardt Treuter Martin Source Type: research
Role of Supplements in the Management of COVID-19 - A Comprehensive Review
Infect Disord Drug Targets. 2023 Mar 10. doi: 10.2174/1871526523666230310094646. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and patients with COVID-19 may be treated primarily with SARS CoV-2-targeting drugs and the therapeutic agents assisting in the management of COVID-19 complications. This review focuses on the supplements like vitamins, minerals, herbal constituents, and others that help prevent or manage negative outcomes among COVID-19 patients. The literature was searched in databases such as Medline/PubMed Central/...
Source: Infectious Disorders Drug Targets - March 10, 2023 Category: Infectious Diseases Authors: Rajkapoor Balasubramanian Naina Mohamed Pakkir Maideen Sudha Muthusamy Sambathkumar Ramanathan Mohamed Harsath Jahir Hussain Source Type: research
Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage
Arch Toxicol. 2022 Mar 28. doi: 10.1007/s00204-022-03267-5. Online ahead of print.ABSTRACTNeonicotinoids are the most widely used pesticides in the world. However, research studies have shown that it can affect the cognitive abilities and health of non-target bees and other wild pollinators by inducing DNA damage, apoptosis and mitochondrial damage, injure to its central nervous system, and it is even developmentally neurotoxic to mammals and humans, with mitochondria being an important target of neonicotinoids. Therefore, this article reviews the role of mitochondrial morphology, calcium ions (Ca2+) homeostasis, respirato...
Source: Archives of Toxicology - March 28, 2022 Category: Toxicology Authors: Xiaoqing Xu Xiaohui Wang Yaqin Yang Irma Ares Marta Mart ínez Bernardo Lopez-Torres Mar ía-Rosa Martínez-Larrañaga Xu Wang Arturo Anad ón Mar ía-Aránzazu Martinez Source Type: research
