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Drug: Acetylcysteine
Nutrition: Calcium
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Total 55 results found since Jan 2013.
Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus-Induced Mitochondrial Damage
CONCLUSIONS: Current study indicates that the mitochondrial fragmentation induced by hepatitis B virus infection can be reduced after antioxidant treatment pointing toward exploring better drug targets for the prevention of hepatitis B virus-induced mitochondrial frag- mentation and associated liver damage.PMID:37565795 | DOI:10.5152/tjg.2023.21290
Source: The Turkish Journal of Gastroenterology - August 11, 2023 Category: Gastroenterology Authors: Kehkshan Jabeen Aneela Javed Sobia Manzoor Shaheen Shahzad Source Type: research
Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation
Eur J Pharmacol. 2022 Oct 25:175343. doi: 10.1016/j.ejphar.2022.175343. Online ahead of print.ABSTRACTChemerin is an adipokine involved in regulating energy homeostasis and reproductive function. Excessive sympathetic activity contributes to hypertension, chronic heart failure and chronic renal disease. Hypothalamic paraventricular nucleus (PVN) is crucial in regulating sympathetic activity and blood pressure. The present study is designed to investigate the roles of chemerin in the PVN in regulating sympathetic activity and blood pressure and underlying mechanisms. Microinjections were performed in the bilateral PVN in ma...
Source: European Journal of Pharmacology - October 28, 2022 Category: Drugs & Pharmacology Authors: Jing-Xiao Wang Xiao-Li Wang Zhi-Qin Xu Yue Zhang Dong Xue Rong Zhu Qi Chen Yue-Hua Li Guo-Qing Zhu Xiao Tan Source Type: research
S-limonene protects the heart in an experimental model of myocardial infarction induced by isoproterenol: Possible involvement of mitochondrial reactive oxygen species
CONCLUSION: Our data show that s-limonene promotes cardioprotection against MI injury, probably through inhibition of increased Ca2+ and attenuation of oxidative stress via CaMKII.PMID:35843301 | DOI:10.1016/j.ejphar.2022.175134
Source: European Journal of Pharmacology - July 17, 2022 Category: Drugs & Pharmacology Authors: Paula Rhana Guilherme Mendes Barros Vin ícius Cisneiros de Oliveira Santos Alexandre Dantas Costa Danillo Menezes Dos Santos Weslley Fernandes-Braga Aim ée Obolari Durço M árcio Roberto Viana Santos Danilo Roman-Campos Carla Maria Lins de Vasconcelos Source Type: research
Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells
This study provides a further mechanistic understanding of kidney damage, and co-exposure impact is worthy of concern and should be considered to improve the accuracy of environmental health assessment.PMID:35753275 | DOI:10.1016/j.ecoenv.2022.113790
Source: Ecotoxicology and Environmental Safety - June 26, 2022 Category: Environmental Health Authors: Yi Zhang Bo Hu Xiaolan Qian Guangtao Xu Xin Jin Deqing Chen Jie Tang Long Xu Source Type: research
Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage
Arch Toxicol. 2022 Mar 28. doi: 10.1007/s00204-022-03267-5. Online ahead of print.ABSTRACTNeonicotinoids are the most widely used pesticides in the world. However, research studies have shown that it can affect the cognitive abilities and health of non-target bees and other wild pollinators by inducing DNA damage, apoptosis and mitochondrial damage, injure to its central nervous system, and it is even developmentally neurotoxic to mammals and humans, with mitochondria being an important target of neonicotinoids. Therefore, this article reviews the role of mitochondrial morphology, calcium ions (Ca2+) homeostasis, respirato...
Source: Archives of Toxicology - March 28, 2022 Category: Toxicology Authors: Xiaoqing Xu Xiaohui Wang Yaqin Yang Irma Ares Marta Mart ínez Bernardo Lopez-Torres Mar ía-Rosa Martínez-Larrañaga Xu Wang Arturo Anad ón Mar ía-Aránzazu Martinez Source Type: research
