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D-mannose for preventing and treating urinary tract infections
CONCLUSIONS: There is currently little to no evidence to support or refute the use of D-mannose to prevent or treat UTIs in all populations. This review highlights the severe lack of high-quality RCTs testing the efficacy of D-mannose for UTIs in any population. Despite UTIs being one of the most common adult infections (affecting 50% of women at least once in their lifetime) and the growing global antimicrobial resistance, we found very few studies that adequately test this alternative treatment. Future research in this field requires, in the first instance, a single adequately powered RCT comparing D-mannose with placebo...
Source: Cochrane Database of Systematic Reviews - August 30, 2022 Category: General Medicine Authors: Tess E Cooper Claris Teng Martin Howell Armando Teixeira-Pinto Allison Jaure Germaine Wong Source Type: research

N-acetylcysteine for non-paracetamol (acetaminophen)-related acute liver failure.
CONCLUSIONS: The available evidence is inconclusive regarding the effect of N-acetylcysteine compared with placebo or no N-acetylcysteine, as an adjunct to usual care, on mortality or transplant rate in non-paracetamol-induced acute liver failure. Current evidence does not support the guideline suggestion to use N-acetylcysteine in adults with non-paracetamol-related acute liver failure, nor the rising use observed in clinical practice. The uncertainty based on current scanty evidence warrants additional randomised clinical trials with non-paracetamol-related acute liver failure evaluating N-acetylcysteine versus placebo, ...
Source: Cochrane Database of Systematic Reviews - December 9, 2020 Category: General Medicine Authors: Siu JT, Nguyen T, Turgeon RD Tags: Cochrane Database Syst Rev Source Type: research

N -acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review protocol
Discussion The aim of this review is to provide evidence on the effectiveness and safety of NAC in non-paracetamol DILI. We anticipate that the results could aid health care practitioners, researchers and policymakers in the decision-making regarding the use of NAC in patients with non-paracetamol DILI. Systematic review registration PROSPERO CRD42014008771
Source: Systematic Reviews - June 12, 2015 Category: Global & Universal Source Type: research

Pharmacotherapies for cannabis dependence.
CONCLUSIONS: There is incomplete evidence for all of the pharmacotherapies investigated, and for many of the outcomes the quality was downgraded due to small sample sizes, inconsistency and risk of attrition bias. The quantitative analyses that were possible, combined with general findings of the studies reviewed, indicate that SSRI antidepressants, mixed action antidepressants, atypical antidepressants (bupropion), anxiolytics (buspirone) and norepinephrine reuptake inhibitors (atomoxetine) are probably of little value in the treatment of cannabis dependence. Preparations containing THC are of potential value but, given t...
Source: Cochrane Database of Systematic Reviews - December 17, 2014 Category: Journals (General) Authors: Marshall K, Gowing L, Ali R, Le Foll B Tags: Cochrane Database Syst Rev Source Type: research

Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.
CONCLUSIONS: We found no evidence to recommend the use of either nebulized or oral thiol derivatives in people with cystic fibrosis. There are very few good quality trials investigating the effect of these medications in cystic fibrosis, and further research is required to investigate the potential role of these medications in improving the outcomes of people with cystic fibrosis. PMID: 23852992 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 12, 2013 Category: Journals (General) Authors: Tam J, Nash EF, Ratjen F, Tullis E, Stephenson A Tags: Cochrane Database Syst Rev Source Type: research