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Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis
Immunobiology. 2021 Oct 25;226(6):152148. doi: 10.1016/j.imbio.2021.152148. Online ahead of print.ABSTRACTVisceral leishmaniasis (VL) or Kala-azar is a vector borne protozoan infection caused by Leishmania donovani in the Indian subcontinent mainly India, Nepal and Bangladesh. It is a major public health problem in these countries mostly affecting the socio-economically poor population. Leishmaniasis ranks the third most important disease after malaria and filariasis but is still considered as one of the neglected tropical diseases of the world. For development of better therapeutic agents and effective vaccine against VL,...
Source: Immunobiology - November 13, 2021 Category: Allergy & Immunology Authors: Rasmita Khatonier Giasuddin Ahmed Pallab Sarmah Kanwar Narain Abdul Mabood Khan Source Type: research

Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis - A review
Biomed Pharmacother. 2021 Jul 20;141:111920. doi: 10.1016/j.biopha.2021.111920. Online ahead of print.ABSTRACTThe study of tropical diseases like leishmaniasis, a parasitic disease, has not received much attention even though it is the second-largest infectious disease after malaria. As per the WHO report, a total of 0.7-1.0 million new leishmaniasis cases, which are spread by 23 Leishmania species in more than 98 countries, are estimated with an alarming 26,000-65,000 death toll every year. Lack of potential vaccines along with the cost and toxicity of amphotericin B (AmB), the most common drug for the treatment of leishm...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Pragya Prasanna Prakash Kumar Saurabh Kumar Vinod Kumar Rajana Vishnu Kant Surendra Rajit Prasad Utpal Mohan V Ravichandiran Debabrata Mandal Source Type: research