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Exploring the experiences and challenges for patients undergoing cranioplasty: a mixed-methods study protocol
This study hopes to understand some of these issues and therefore help inform clinicians of some of the difficulties and perceptions that patients and their relatives may have. Methods and analysis A mixed-methods study. Data will be collected through focus groups with healthcare professionals (HCPs) and semi-structured interviews with patients and their relatives, field notes, a researcher diary and a patient questionnaire. Different perspectives will be brought together through method triangulation. Patient and relative data will be analysed using interpretive phenomenological analysis, and HCPs data will be analysed th...
Source: BMJ Open - April 22, 2022 Category: General Medicine Authors: Mee, H., Clement, C., Anwar, F., Whiting, G., Timofeev, I., Helmy, A., Hutchinson, P. J., Kolias, A. G. Tags: Open access, Rehabilitation medicine Source Type: research

Understanding determinants of acute stroke thrombolysis using the tailored implementation for chronic diseases framework: a qualitative study
The Tailored Implementation in Chronic Disease (TICD) framework is a comprehensive framework describing the determinants of implementation success that has been used extensively in primary care settings. We ex...
Source: BMC Health Services Research - March 20, 2019 Category: General Medicine Authors: Lesli E. Skolarus, Gina M. Neshewat, Lacey Evans, Molly Green, Narmeen Rehman, Zach Landis-Lewis, Jillian Welsh Schrader and Anne E. Sales Tags: Research article Source Type: research

Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer.
Abstract Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia. The discovery of oxygen sensing provides fundamental knowledge of a stunningly elegant molecular machinery; it also promises development of new therapeutics for serious diseases such as cancer. As a result of their impressive contributions to our understanding of the mechanisms by which cells sense oxy...
Source: Upsala Journal of Medical Sciences - June 23, 2020 Category: General Medicine Authors: Claesson-Welsh L Tags: Ups J Med Sci Source Type: research

How are adults with capacity-affecting conditions and associated communication difficulties included in ethically sound research? A documentary-based survey of ethical review and recruitment processes under the research provisions of the Mental Capacity Act (2005) for England and Wales
Conclusions People with capacity-affecting conditions and associated communication difficulties continue to be excluded from research, with recruitment efforts largely concentrated around participant-facing documentation. There is a need for a more nuanced approach if such individuals are to be included in ethically sound research.
Source: BMJ Open - March 31, 2022 Category: General Medicine Authors: Bunning, K., Jimoh, O. F., Heywood, R., Killett, A., Ryan, H., Shiggins, C., Langdon, P. E. Tags: Open access, Ethics Source Type: research

Impact of multimorbidity and complex multimorbidity on mortality among older Australians aged 45 years and over: a large population-based record linkage study
Conclusion MM and CMM were common in older Australian adults; and MM was a better predictor of all-cause mortality risk than CMM. Higher mortality risk in those aged 45–59 years indicates tailored, person-centred integrated care interventions and better access to holistic healthcare are needed for this age group.
Source: BMJ Open - July 26, 2022 Category: General Medicine Authors: Kabir, A., Tran, A., Ansari, S., Conway, D. P., Barr, M. Tags: Open access, Geriatric medicine Source Type: research

Factors associated with discharge from hospital to residential aged care for younger people with neuropsychiatric disorders: an exploratory case-control study in New South Wales, Australia
Conclusions There are multiple intersecting and interacting pathways culminating in discharge from hospital to RAC among younger people with neuropsychiatric disorders. Improved capacity for interdisciplinary home care and alternative housing and support options for people with high support needs are required.
Source: BMJ Open - December 1, 2022 Category: General Medicine Authors: Cvejic, R. C., Watkins, T. R., Walker, A. R., Reppermund, S., Srasuebkul, P., Draper, B., Withall, A., Winkler, D., Honan, I., Mackechnie, D., Trollor, J. Tags: Open access, Epidemiology Source Type: research

Differences in the pre-hospital management of women and men with stroke by emergency medical services in New South Wales
Med J Aust. 2022 Dec 10. doi: 10.5694/mja2.51809. Online ahead of print.NO ABSTRACTPMID:36495870 | DOI:10.5694/mja2.51809
Source: Medical Journal of Australia - December 10, 2022 Category: General Medicine Authors: Xia Wang Cheryl Carcel Mark Woodward Source Type: research

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