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Total 1461 results found since Jan 2013.
Clinical Characteristics and Outcomes of Chagas Disease in the United States: A Multicenter Retrospective Analysis
Am J Trop Med Hyg. 2023 Sep 11:tpmd230361. doi: 10.4269/ajtmh.23-0361. Online ahead of print.ABSTRACTChagas disease affects approximately 300,000 patients in the United States. We evaluated a multicenter U.S.-based network to obtain clinical characteristics and outcomes of chronic Chagas disease by disease forms. This was a U.S.-based, multicenter, population-based, retrospective cohort study. We queried TriNetX, a global research network, to identify patients with dual-positive IgG serology for Trypanosoma cruzi. We captured outcomes of interest for up to 5 years. We found 429 patients with evidence of dual-positive T. cr...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Andr és F Henao-Martínez Christian Olivo-Freites Nelson I Agudelo Higuita Carolina Ferraz Carlos Franco-Paredes Jose Tuells Laila Woc-Colburn Salvador Villalpando-Carri ón Daniel B Chastain Anis Rassi Source Type: research
Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news
Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome
CONCLUSIONS: Patients with MetS have an increased frequency of cardiac events following bariatric surgery. Future studies should determine if optimization of 1 or more components of MetS or other related co-morbidities reduces the cardiovascular risk for patients.PMID:37659898 | DOI:10.1016/j.soard.2023.07.009
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 2, 2023 Category: Surgery Authors: Maryna Chumakova-Orin Jennifer L Ingram Loretta G Que Neha Pagidipati Alexander Gordee Maragatha Kuchibhatla Keri A Seymour Source Type: research
Healthcare expenditure trends among adult stroke patients in the United States, 2011-2020
In the US, between 2018 and 2019, approximately $57 billion were expended on stroke and related conditions. The aim of this study was to understand trends in direct healthcare expenditures among stroke patients using novel cost estimation methods and a nationally representative database.
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2023 Category: Neurology Authors: Venkataraghavan Ramamoorthy, Kelvin Chan, Mukesh Roy, Anshul Saxena, Md Ashfaq Ahmed, Zhenwei Zhang, Sandeep Appunni, Ronnie Thomas, Peter McGranaghan, Michael McDermott, Felipe De Los Rios La Rosa, Muni Rubens Source Type: research
Device use trends in neuroendovascular procedures in the United States from 2015 to 2020
CONCLUSION: Our study demonstrates an increase in the use of flow-diverting stents, nondiverting stents, carotid stents, and reperfusion devices for acute ischemic stroke intervention between 2015 and 2020. Coil use for aneurysmal treatment has declined.PMID:37642975 | DOI:10.1177/15910199231196329
Source: Interventional Neuroradiology - August 29, 2023 Category: Radiology Authors: Arjun Rohit Adapa Fazeel M Siddiqui Aditya S Pandey Source Type: research
