• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling.
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu, Jianxin Chen, Ruocong Yang, Feipeng Duan, Shaojing Li, Xiuping Chen Tags: RESEARCH PAPER Source Type: research

Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post ‐ischaemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsAs TBN can simultaneously provide neuroprotection and pro‐neurogenic effects, it may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischaemic stroke.
Source: British Journal of Pharmacology - December 22, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐Yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research

Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post ‐ischemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsTBN's ability to simultaneously provide neuroprotection and pro‐neurogenic effect may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischemic stroke.
Source: British Journal of Pharmacology - November 21, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research