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Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients.
Abstract We aimed to examine whether baseline neutrophil counts affected the risk of new-onset proteinuria in hypertensive patients, and, if so, whether folic acid treatment is particularly effective in proteinuria prevention in such a setting. A total of 8,208 eligible participants without proteinuria at baseline were analyzed from the renal sub-study of the China Stroke Primary Prevention Trial (CSPPT). Participants were randomized to receive a double-blind daily treatment of 10mg enalapril and 0.8mg folic acid (n=4,101) or 10mg enalapril alone (n=4,107). The primary outcome was new-onset proteinuria, defined as...
Source: The British Journal of Nutrition - December 14, 2020 Category: Nutrition Authors: Zhang Z, Liu M, Zhang Y, Zhou C, He P, Li H, Li J, Zhang Y, Liang M, Wang B, Xu X, Wang X, Huo Y, Hou FF, Nie J, Xu X, Qin X Tags: Br J Nutr Source Type: research

Prediction Model for the Efficacy of Folic Acid Therapy on Hyperhomocysteinaemia based on genetic risk score methods.
Abstract No risk assessment tools for the efficacy of folic acid treatment for hyperhomocysteinaemia (HHcy) have been developed. We aimed to use two common genetic risk score (GRS) methods to construct prediction models for the efficacy of folic acid therapy on HHcy, and the best gene-environment prediction model was screened out. A prospective cohort study enrolling 638 HHcy patients was performed. We used logistic regression model to estimate the associations of two GRS methods with the efficacy. Performances were compared using area under the receiver operating characteristic curve (AUC). The simple count genet...
Source: The British Journal of Nutrition - April 1, 2019 Category: Nutrition Authors: Du B, Zhang C, Yue L, Ren B, Zhao Q, Li D, He Y, Zhang W Tags: Br J Nutr Source Type: research