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Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Spectrum of transthyretin gene mutations and clinical characteristics of Polish patients with cardiac transthyretin amyloidosis.
CONCLUSIONS: According to available research, this is the first time types of TTR mutations and clinical characteristics of Polish patients with cardiac hereditary ATTR have been reported. Previous literature data about Polish background in families with p.Phe53Leu mutation and the present results, suggest that this TTR mutation might be endemic in the Polish population. PMID: 32789836 [PubMed - as supplied by publisher]
Source: Cardiology Journal - August 12, 2020 Category: Cardiology Authors: Gawor M, Holcman K, Franaszczyk M, Lipowska M, Michałek P, Teresińska A, Bilińska ZT, Rubiś P, Kostkiewicz M, Szot W, Podolec P, Grzybowski J Tags: Cardiol J Source Type: research

Predictors of mortality and cardiovascular outcomes in Emery-Dreifuss Muscular Dystrophy in a long-term follow-up
CONCLUSIONS: LMNA mutation and higher NT-proBNP concentration were associated with increased mortality in EDMD. Lower TAPSE was a predictor of a composite secondary endpoint in EDMD.PMID:34783354 | DOI:10.33963/KP.a2021.0159
Source: Polish Heart Journal - November 16, 2021 Category: Cardiology Authors: Micha ł Marchel Agnieszka Madej-Pilarczyk Roman Steckiewicz Przemys ław Stolarz Micha ł Peller Agata Tymi ńska Ewa Ostrowska Krzysztof Oziera ński Pawe ł Balsam Marcin Grabowski Grzegorz Opolski Source Type: research