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Optimal anticoagulation in elderly patients with atrial fibrillation: Which drug at which dose?
Kardiol Pol. 2022 Feb 15. doi: 10.33963/KP.a2022.0046. Online ahead of print.ABSTRACTAging is an important risk factor of adverse events in elderly patients with atrial fibrillation (AF) and complicates the management of anticoagulation. Underuse of oral anticoagulants (OACs) is common in elderly patients because of comorbidities, altered physiological function of multiple organs, fragile features, risk of falls, and the lack of randomized controlled trials (RCTs) specifically for elderly patients. Nevertheless, current data still support OACs use for reducing ischemic stroke with positive net clinical benefits. Sub-analys...
Source: Polish Heart Journal - February 15, 2022 Category: Cardiology Authors: Jo-Nan Liao Yi-Hsin Chan Ling Kuo Chuan-Tsai Tsai Su-Shen Lim Tze-Fan Chao Source Type: research

Antiphosholipid syndrome and the risk of myocardial infarction: current evidence and uncertainties.
Abstract Antiphospholipid syndrome (APS) encompasses a wide spectrum of disease manifestations that may prevail in the form of venous or arterial thrombosis or lead to pregnancy complications in the presence of persisting antiphospholipid (aPL) antibodies. Unlike in the case of congenital thrombophilias where venous thromboses are more likely to occur as compared to arterial events, aPL antibodies may cause thrombosis in both types of vascular system, often including the coronary or cerebral arteries leading to myocardial infarction (MI) or stroke. In this review we summarize the complex pathomechanisms leading to...
Source: Polish Heart Journal - December 5, 2019 Category: Cardiology Authors: Lóczi L, Kappelmayer J, Tarr T, Bagoly Z Tags: Kardiol Pol Source Type: research

Non-vitamin K antagonist oral anticoagulants (NOACs) in the treatment of coronary and peripheral atherosclerosis. Expert Consensus.
Abstract Oral anticoagulants (OAC) are widely used for prevention of systemic thromboembolism, including the reduction of the risk of stroke in patients with atrial fibrillation (AF) and prosthetic heart valves. There is also an increasing population of patients who require not only OACs, but also double antiplatelet therapy (DAPT). A typical example is a patient with AF and stable coronary artery disease or acute coronary syndrome (ACS), treated by percutaneous coronary intervention (PCI). In recent years, with the introduction of NOACs, triple or dual therapy has become safer. Regardless of these indications for...
Source: Polish Heart Journal - February 25, 2019 Category: Cardiology Authors: Witkowski A, Barylski M, Filipiak KJ, Gierlotka M, Legutko J, Lesiak M, Stępińska J, Wojakowski W Tags: Kardiol Pol Source Type: research

Differences in knowledge among patients with atrial fibrillation receiving non-vitamin K antagonist oral anticoagulants and vitamin K antagonists.
CONCLUSIONS: The knowledge of arrhythmia and anticoagulation is better regarding the safety issues among subjects on NOACs compared with those on VKAs. Irrespective of the type of oral anticoagulation therapy, education of AF patients should be improved. PMID: 29528483 [PubMed - indexed for MEDLINE]
Source: Kardiologia Polska - November 8, 2018 Category: Cardiology Authors: Konieczyńska M, Sobieraj E, Bryk AH, Dębski M, Polak M, Podolec P, Małecka B, Pająk A, Desteghe L, Heidbuchel H, Undas A Tags: Kardiol Pol Source Type: research

Differences in knowledge among patients with atrial fibrillation receiving NOACs and vitamin K antagonists.
CONCLUSIONS: The knowledge of arrhythmia and anticoagulation is better regarding the safety issues among subjects on NOACs compared with VKA. Irrespective of the type of OAC therapy, education of AF patients should be improved. PMID: 29528483 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - March 12, 2018 Category: Cardiology Authors: Konieczyńska M, Sobieraj E, Bryk AH, Dębski M, Polak M, Podolec P, Małecka B, Pająk A, Desteghe L, Heidbuchel H, Undas A Tags: Kardiol Pol Source Type: research

Stroke prevention in AF patients in Poland and other European countries: insights from the GARFIELD-AF registry.
CONCLUSIONS: The GARFIELD-AF Registry data shows how distant every day clinical practice is from the guidelines. It shows that still in Poland, as well as in the rest of Europe, too many patients with low stroke risk are treated with anticoagulants, while too frequently patients at the high stroke risk are left with no stroke prevention. Although the tendency to use non-vitamin K oral anticoagulants grows comparably in Poland and in the rest of Europe, the proportion of patients with intermediate and high stroke risk does not grow and more patients at low stroke risk are treated with anticoagulants. PMID: 26365937 [Pu...
Source: Polish Heart Journal - September 14, 2015 Category: Cardiology Authors: Stępińska J, Kremis E, Konopka A, Wożakowska-Kapłon B, Ruszkowski P, Kukla P, Kayani G Tags: Kardiol Pol Source Type: research