Non-vitamin K antagonist oral anticoagulants (NOACs) in the treatment of coronary and peripheral atherosclerosis. Expert Consensus.

Non-vitamin K antagonist oral anticoagulants (NOACs) in the treatment of coronary and peripheral atherosclerosis. Expert Consensus. Kardiol Pol. 2019 Feb 25;: Authors: Witkowski A, Barylski M, Filipiak KJ, Gierlotka M, Legutko J, Lesiak M, Stępińska J, Wojakowski W Abstract Oral anticoagulants (OAC) are widely used for prevention of systemic thromboembolism, including the reduction of the risk of stroke in patients with atrial fibrillation (AF) and prosthetic heart valves. There is also an increasing population of patients who require not only OACs, but also double antiplatelet therapy (DAPT). A typical example is a patient with AF and stable coronary artery disease or acute coronary syndrome (ACS), treated by percutaneous coronary intervention (PCI). In recent years, with the introduction of NOACs, triple or dual therapy has become safer. Regardless of these indications for the use of NOACs rivaroxaban in the reduced dose has proven to efficiently reduce the risk of further thrombotic events when added to DAPT in patients who have suffered an ACS. However, such therapy increases the incidence of bleeding complications. Interesting was also the potential impact of the pleiotropic mechanism of action of NOACs through PAR1 and PAR2 receptors, present on the platelets and many other cells, and changing the course of arterial atherosclerosis. COMPASS trial has shown that in the group treated with rivaroxaban combined with aspirin (ASA), the primary outcome...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research

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Publication date: December 2019Source: Food Research International, Volume 126Author(s): Dele Raheem, António Raposo, Oluwatoyin Bolanle Oluwole, Maaike Nieuwland, Ariana Saraiva, Conrado CarrascosaAbstractGlobally, there is a need to seek alternative sources of protein in addition to meat. This has led to considerable interest in edible insects. Such insects form part of cultures and diets in many Asian and African countries, and are an excellent source of essential nutrients, minerals, vitamins and proteins. Furthermore, they have been reported to be sustainable. The ecological importance of insects is related to ...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 20 October 2019Source: Microchemical JournalAuthor(s): Amira H. Kamal, Aya A. Marie, Sherin F. HammadAbstractReversed-phase high performance liquid chromatographic method (RP-HPLC) was applied for simultaneous determination of aspirin (ASP) and omeprazole (OMP) in presence of salicylic acid (SA) as the most common degradation product of ASP. The drugs were exposed to different stress conditions including acid, alkali, neutral hydrolysis, oxidation, and photodegradation. The separation was carried out on the Thermo Scientific Hypersil ODS column (250 × 4.6 mm, 5µm) column. ...
Source: Microchemical Journal - Category: Chemistry Source Type: research
A 59-year-old woman presented with extreme thirst. She was a current smoker (35 pack-years) and had extensive peripheral vascular disease, including asymptomatic carotid artery stenosis. She had hypertension that was well regulated with a calcium channel blocker (nifedipine 30 mg once daily). Her thirst had become gradually worse over 6 months and was affecting her quality of life. During outpatient evaluation at a regional hospital, her thirst was accompanied by polydipsia and polyuria (both ∼6 l/d).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
CONCLUSIONS This study contributed to the knowledge on the profile of confirmed cases of high severity yellow fever. The main factors associated with death were changes in renal excretion and elevated serum transaminases, especially ALT. High lethality emphasizes the need for early diagnosis and treatment, and the importance of increasing vaccination coverage.RESUMO OBJETIVO Descrever o perfil cl ínico-epidemiológico dos casos confirmados de febre amarela internados em hospital geral de referência para doenças infecciosas no estado do Rio de Janeiro, Brasil, de 11 de março de 2017 a 15 de ...
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs). This achieves pathogen immobilization or initiation of thrombosis, yet the molecular mechanisms of NET formation remain elusive. Peptidyl arginine deiminase-4 (PAD4) achieves protein citrullination and has been intricately linked to NET formation. Here we show that citrullination represents a major regulator of proteolysis in the course of NET formation. Elevated cytosolic calcium levels trigger both peptidylarginine deiminase-4 (PAD4) and calpain activity ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease.
Source: Diabetology International - Category: Endocrinology Source Type: research
Objectives: To determine the feasibility and impact of real-time anti-factor Xa (aFXa) level monitoring and enoxaparin dose adjustment in orthopaedic trauma. To examine the adequacy of standard fixed-dose enoxaparin chemoprophylaxis and to examine whether patient-specific factors influence enoxaparin metabolism. Design: Prospective cohort. Setting: Academic Level-I trauma center. Patients: Postoperative adult orthopaedic trauma patients undergoing acute fracture or nonunion surgery of the pelvis, acetabulum, or lower extremity placed on 30 mg of enoxaparin twice daily. Intervention: Peak steady-state aFXa lev...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
This study explored the association between serum vitamin D levels and urinary tract infections in pregnant women.Study designIn this case control study, 187 participants including, 97 pregnant women diagnosed as a symptomatic UTI (case group) and 90 matched healthy pregnant women (control group) were consecutively enrolled from prenatal care clinic of Imam Reza Hospital in Urmia, North West of Iran. The two groups were matched for trimester and parity, and sexual intercourse. Blood samples were collected from both groups. Chemiluminescent immunoassay (CLIA) was used to evaluate the serum vitamin D levels. We used a binary...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
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