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Total 62514 results found since Jan 2013.

Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccines
CDC researchers have developed a potent immunogenic enhancer polypeptide useful for improving flavivirus vaccines. Flaviviruses such as dengue virus (1, 2, 3 and 4), Japanese encephalitis virus, Murray Valley encephalitis virus, St. Louis encephalitis virus, yellow fever virus and tick-borne encephalitis virus are a great burden on public health. This technology describes an identified CD4+ T cell epitope occurring within the E-glycoprotein of West Nile virus and methods of using this polypeptide to increase vaccine immunogenicity in monovalent vaccines.Many attempts to develop multivalent flavivirus vaccines have encounte...
Source: NIH OTT Licensing Opportunities - July 9, 2014 Category: Research Authors: ajoyprabhu3 Source Type: research

Diagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis Infections
Syphilis is a sexually transmitted infection that remains a global health threat. The World Health Organization estimates that more than 12 million new cases are reported in adults annually worldwide. Syphilis rates are rising domestically as well. The rapid plasma reagin (RPR) test (including automated version) and the Venereal Disease Research Laboratory (VDRL) test are commercially available and used to detect/screen active infection.CDC researchers have also developed a rapid serological test that detects active syphilis infections. The test is an immunoassay that uses modified cardiolipin as an antigen to detect anti-...
Source: NIH OTT Licensing Opportunities - September 27, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

PK/PD, Safety and Tolerability of PHP-201 Topical Eye Drop in Korean and Japanese Healthy Subjects
Condition:   Healthy Volunteer Intervention:   Drug: PHP-201 0.5% ophthalmic solution (topical eye drop) Sponsor:   pH Pharma Completed
Source: ClinicalTrials.gov - July 16, 2018 Category: Research Source Type: clinical trials

Attentional signals projecting centrifugally to the avian retina: A dual contribution to visual search
Vision Res. 2022 Feb 11;195:108016. doi: 10.1016/j.visres.2022.108016. Online ahead of print.ABSTRACTAmong vertebrates, birds have a particularly well-developed retinopetal system, i.e., the centrifugal system projecting from the brain to the retina. Primary, secondary and tertiary neurons of the retinopetal system connect serially in a one-to-one-to-one fashion, thereby assembling several thousand retinopetal modules projecting in parallel to the retina. The signal conveyed by the retinopetal system enhances the visual responses of retinal ganglion cells (RGCs), and each retinopetal module may facilitate the RGCs in a top...
Source: Vision Research - February 14, 2022 Category: Opthalmology Authors: Hiroyuki Uchiyama Hiroshi Ohno Takuto Kawasaki Yuhki Owatari Takahiro Narimatsu Yusaku Miyanagi Taiga Maeda Source Type: research