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Association of a genetic variant in the AKT gene locus and cardiovascular risk factors.
Authors: Kermanshahi F, Ghazizadeh H, Hussein NA, Amerizadeh F, Samadi S, Tayefi M, Kamel Khodabandeh A, Moohebati M, Ebrahimi M, Esmaily H, Sahebi R, Abdulkarimi R, Mousavi SAR, Ferns GA, Avan A, Ghayour-Mobarhan M Abstract Cardiovascular disease (CVDs) is the leading cause of morbidity and death worldwide. Most genetic variants could be identified by several genome-wide-association-studies (GWAS), including within genes encoding proteins involved in the AKT/PI3K pathways that are related with an increased risk of metabolic syndrome and CVDs. Therefore, due to the importance of genetic variants in the prognosis of...
Source: Cellular and Molecular Biology - June 18, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Association of Interleukin-10 -592 C   >  A gene polymorphism with coronary artery disease: A case-control study and meta-analysis.
CONCLUSION: Although our research findings support a significant association of genetic polymorphism in the IL10 gene with cardiovascular diseases, this finding cannot be confirmed in meta-analysis. Further functional analysis and evaluation of this marker in a multicenter setting are needed to establish its value as a risk stratification marker. PMID: 33472122 [PubMed - as supplied by publisher]
Source: Cytokine - January 17, 2021 Category: Molecular Biology Authors: Ghalandari M, Jamialahmadi K, Nik MM, Pirhoushiaran M, Mirhafez SR, Rooki H, Avan A, Ghazizadeh H, Moohebati M, Nohtani M, Zaimkohan H, Ferns GA, Pasdar A, Ghayour-Mobarhan M Tags: Cytokine Source Type: research