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Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial
Blood Adv. 2023 Feb 3:bloodadvances.2022008539. doi: 10.1182/bloodadvances.2022008539. Online ahead of print.ABSTRACTData from small clinical trials in the USA and India suggest zinc supplementation reduces infection in adolescents and adults with sickle cell anemia (SCA), but no studies of zinc supplementation for infection prevention have been conducted in young children with SCA living in Africa, who have higher infection rates. We conducted a randomized double-blind placebo-controlled trial to assess the effectiveness of zinc supplementation for prevention of severe or invasive infections in Ugandan children 1.00-4.99 ...
Source: Adv Data - February 3, 2023 Category: Epidemiology Authors: Ruth Namazzi Robert O Opoka Andrea L Conroy Dibyadyuti Datta Abner Tagoola Caitlin Bond Michael J Goings Moon-Suhn Ryu Sarah E Cusick Nancy F Krebs Jeong Hoon Jang Wanzhu F Tu Russell E Ware Chandy C John Source Type: research

Impact of Smoking on Functional Prognosis after Ischemic Stroke according to Deprivation: A Prospective Cohort Study
Conclusion: The effect of smoking on functional prognosis after ischemic stroke varied according to deprivation status, with poorer outcomes observed in nondeprived patients.Neuroepidemiology
Source: Neuroepidemiology - October 27, 2022 Category: Epidemiology Source Type: research

Comparing Vascular Brain Injury and Stroke by Cranial Magnetic Resonance Imaging, Physician-Adjudication, and Self-Report: Data from the Strong Heart Study
Conclusion: In this community-based cohort, self-report for prior stroke had good performance metrics. A majority of participants with VBI did not have overt, clinically recognized events but did have neurological or cognitive symptoms. Data collection methodology for studies in a resource-limited setting must balance practical limitations in costs, accuracy, feasibility, and research goals.Neuroepidemiology
Source: Neuroepidemiology - August 24, 2021 Category: Epidemiology Source Type: research

Rural Stroke Surveillance and Establishment of Acute Stroke Care Pathway Using Frontline Health Workers in Rural Northwest India: The Ludhiana Experience
Conclusion: ASHAs were able to identify stroke patients in the villages. Despite high numbers of patients reaching health-care facilities within a window period, the hospitals were unable to provide acute stroke treatment like thrombolysis. The health-care system needs to be strengthened to improve stroke care.Neuroepidemiology
Source: Neuroepidemiology - May 5, 2021 Category: Epidemiology Source Type: research

Lifestyle Risk Factors and Findings on Brain Magnetic Resonance Imaging of Older Adult American Indians: The Strong Heart Study
Conclusions: This study found similar associations between smoking and vascular brain injury among American Indians, as seen in other populations. In particular, these findings support the role of smoking as a key correlate for cerebral atrophy.Neuroepidemiology
Source: Neuroepidemiology - June 4, 2019 Category: Epidemiology Source Type: research

Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study
Conclusions: This study found risk factors for cerebrovascular disease in American Indians similar to those seen in other populations and provides additional evidence for the important roles of hypertension and diabetes in promoting cerebral infarcts and brain atrophy, respectively.Neuroepidemiology 2019;52:173 –180
Source: Neuroepidemiology - January 27, 2019 Category: Epidemiology Source Type: research

Impact of intensified pharmaceutical care on health related quality of life in patients with stroke in a tertiary care hospital
ConclusionThe study enables demonstration and application of a pharmaceutical care program among stroke patients to prevent complications to improve HRQoL. This study indicates that pharmaceutical care can be performed in both hospital and community settings as it provides more benefit and positive impact on patient’HRQoL.
Source: Clinical Epidemiology and Global Health - July 11, 2018 Category: Epidemiology Source Type: research

Impact of pharmaceutical care on health related quality of life in patients with stroke in a tertiary care hospital
Conclusion The study enables demonstration and application of a pharmaceutical care program among stroke patients to prevent complications to improve HRQoL. This study indicates that pharmaceutical care can be performed in both hospital and community settings as it provides more benefit and positive impact on patient's HRQoL.
Source: Clinical Epidemiology and Global Health - May 3, 2018 Category: Epidemiology Source Type: research