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First multicentric real-life experience with the combination of CCNU and temozolomide in newly diagnosed < em > MGMT < /em > promoter methylated < em > IDH < /em > wildtype glioblastoma
CONCLUSIONS: The results from this multicentric trial indicate that-under real-life conditions-toxicity and survival estimates are comparable to the CeTeG/NOA-09 trial. TTFields therapy for at least eight weeks in combination with this regimen was independently associated with prolonged survival.PMID:36284931 | PMC:PMC9583686 | DOI:10.1093/noajnl/vdac137
Source: Adv Data - October 26, 2022 Category: Epidemiology Authors: Lazaros Lazaridis Elisabeth Bumes Dorothee C äcilia Spille Tim Schulz Sina Heider Sarina Agkatsev Teresa Schmidt Tobias Blau Christoph Oster Jonas Feldheim Walter Stummer Almuth Friederike Kessler Clemens Seidel Oliver Grauer Peter Hau Ulrich Sure Kathy Source Type: research

Lung toxicity of lomustine in the treatment of progressive gliomas
CONCLUSIONS: Our findings support to limit lung function analyses on CCNU to patients with gliomas and pulmonary risk factors. However, all patients should be closely followed for clinical symptoms of pulmonary restriction.PMID:35664555 | PMC:PMC9155160 | DOI:10.1093/noajnl/vdac068
Source: Adv Data - June 6, 2022 Category: Epidemiology Authors: Corinna Seliger Christina N ürnberg Wolfgang Wick Antje Wick Source Type: research

Effectiveness of bortezomib and temozolomide for eradication of recurrent human glioblastoma cells, resistant to radiation
CONCLUSIONS: Bortezomib and temozolomide effectively destroy cells of a radioresistant recurrent human glioblastoma; proteome mapping of the recurrent GBM cancer cells allows to identify new targets for therapy to improve the treatment results.PMID:34689859 | DOI:10.1016/bs.pbr.2021.06.010
Source: Brain Research - October 25, 2021 Category: Neurology Authors: Oleg Pak Sergei Zaitsev Valery Shevchenko Aruna Sharma Hari Shanker Sharma Igor Bryukhovetskiy Source Type: research