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Non-conventional compounds with potential therapeutic effects against Alzheimer's disease.
Authors: de Castro AA, Soares FV, Pereira AF, Polisel DA, Caetano MS, Leal DHS, da Cunha EFF, Nepovimova E, Kuca K, Ramalho TC Abstract INTRODUCTION: Alzheimer's disease (AD) is the most common cause of dementia. Clinical progress in this pathogenesis field has drawn the attention of researchers, stimulating the investigation of novel treatment methods. Current therapies that deal with cholinesterase inhibitors and/or NMDA antagonists have shown a modest symptomatic potential, increasing the need for research into more efficient therapeutics. The goal of this review is to summarize the advances in, and the potential o...
Source: Expert Review of Neurotherapeutics - April 20, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Traditional Ayurvedic and herbal remedies for Alzheimer's disease: From Bench to Bedside.
Authors: Sharma R, Kuca K, Nepovimova E, Kabra A, Rao MM, Prajapati PK Abstract INTRODUCTION: Alzheimer's disease (AD) is a progressive, neurodegenerative disorder prevalent worldwide among elderly populations. Owing to limited efficacy, side effects and poor patient compliance for current rationally designed therapies, options are being searched from alternate therapies such as Indian (Ayurvedic), Chinese or other traditional systems. Areas covered: Following a comprehensive literature search, the authors provide a review encompassing: (i) pathophysiological changes involved in AD (ii) Ayurvedic holistic approach and...
Source: Expert Review of Neurotherapeutics - March 20, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research