Traditional Ayurvedic and herbal remedies for Alzheimer's disease: From Bench to Bedside.

Traditional Ayurvedic and herbal remedies for Alzheimer's disease: From Bench to Bedside. Expert Rev Neurother. 2019 Mar 18;: Authors: Sharma R, Kuca K, Nepovimova E, Kabra A, Rao MM, Prajapati PK Abstract INTRODUCTION: Alzheimer's disease (AD) is a progressive, neurodegenerative disorder prevalent worldwide among elderly populations. Owing to limited efficacy, side effects and poor patient compliance for current rationally designed therapies, options are being searched from alternate therapies such as Indian (Ayurvedic), Chinese or other traditional systems. Areas covered: Following a comprehensive literature search, the authors provide a review encompassing: (i) pathophysiological changes involved in AD (ii) Ayurvedic holistic approach and herbal medicines to manage dementia and AD, and (iii) Traditional plants and their phytoconstituents effective in AD with description of possible mechanism of action. Expert opinion: Traditional remedies could be adjunct therapeutic options to allay wide-ranging pathological cascades of AD. Ayurveda offers a holistic approach of treatment along with a list of nootropic herbs and formulations that are rich sources of antioxidants, anti-amyloidogenic, neuroprotective, adaptogenic, anti-inflammatory and immunomodulatory compounds that are found to modulate neuro-endocrine-immune activities, enhance memory, intellect, rejuvenate brain functions and improve quality of life. A strong knowledge base of traditional systems c...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research