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Total 277 results found since Jan 2013.

Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation
Toxicol Appl Pharmacol. 2023 Aug 1:116649. doi: 10.1016/j.taap.2023.116649. Online ahead of print.ABSTRACTSteroid-induced avascular necrosis of femoral head (SANFH) is a common disorder worldwide with high disability. Overdose of glucocorticoid (GC) is the most common non-traumatic cause of SANFH. Up until now, there are limited therapeutic strategies for curing SANFH, and the mechanisms underlying SANFH progression remain unclear. Nevertheless, Osteogenic dysfunction is considered to be one of the crucial pathobiological mechanisms in the development of SANFH, which involves mouse bone marrow mesenchymal stem cells (BMSCs...
Source: Toxicology and Applied Pharmacology - August 3, 2023 Category: Toxicology Authors: Qian Liu Yuyang Wu Sisi Li Somy Yoon Jiaxin Zhang Xiaoyi Wang Luoshuang Hu Chenying Su Chunwu Zhang Yungang Wu Source Type: research

The Anti-Inflammatory and Skin Barrier Function Recovery Effects of < em > Schisandra chinensis < /em > in Mice with Atopic Dermatitis
Conclusions: These results suggest that S. chinensis can be used as an alternative to external corticosteroids and that its anti-inflammatory and skin barrier dysfunction-restoring effects are related to the downregulation of pro-inflammatory cytokines and chemokines, such as TNF-α, IL-4, IL-6, IL-8, and TSLP.PMID:37512164 | PMC:PMC10385087 | DOI:10.3390/medicina59071353
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Yoorae Son Wonjin Yang Sangjun Park Jinkyu Yang Soyeon Kim Ji-Hyo Lyu Hyungwoo Kim Source Type: research