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The association between endocrine therapy use and osteoporotic fracture among post-menopausal women treated for early-stage breast cancer in Ontario, Canada
CONCLUSION: We could not detect a significant difference in the rate of osteoporotic fracture among patients treated with an aromatase inhibitor versus tamoxifen. Nonetheless, the risk with tamoxifen was numerically lower and significantly decreased when accounting for total duration of endocrine therapy.PMID:34728119 | DOI:10.1016/j.breast.2021.09.010
Source: Breast - November 3, 2021 Category: Cancer & Oncology Authors: Phillip S Blanchette Melody Lam Britney Le Lucie Richard Salimah Z Shariff Alexandra M Ou édraogo Kathleen I Pritchard Jacques Raphael Ted Vandenberg Ricardo Fernandes Danielle N Desautels Kelvin K W Chan Craig C Earle Source Type: research

Predictive significance of an optimized panel for basal-like breast cancer: Results from the Canadian Cancer Trials Group MA.5 and MA.12 phase III clinical trials
CONCLUSIONS: The nestin/INPP4B immunohistochemical panel identifies women with basal breast cancers who benefit from non-anthracycline chemotherapy but not endocrine adjuvant treatments.PMID:34615722 | DOI:10.1158/1078-0432.CCR-21-1942
Source: Clinical Cancer Research - October 7, 2021 Category: Cancer & Oncology Authors: Karama Asleh Dongsheng Tu Dongxia Gao Vivien Bramwell Mark N Levine Kathleen I Pritchard Lois E Shepherd Torsten O Nielsen Source Type: research

Temporal manipulation of KCC3 expression in juvenile or adult mice suggests irreversible developmental deficit in HSMN/ACC
In this study, we used two separate mouse models, which when combined to the PV-CreERT2 tamoxifen inducible system, allowed us to 1) disrupt KCC3 expression in adulthood or juvenile periods; and 2) re-introduce KCC3 expression in mice that first develop with a non-functional cotransporter. We show that disrupting or re-introducing KCC3 in the adult mouse has no effect on locomotor behavior, indicating that expression of KCC3 is critical during embryonic development and/or the perinatal period and that once the disease has started, re-expressing a functional cotransporter fails to change the course of HMSN/ACC.PMID:33596149...
Source: American Journal of Physiology. Cell Physiology - February 17, 2021 Category: Cytology Authors: Bianca Flores Eric Delpire Source Type: research