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Polymorphisms and gene expression of metalloproteinases and their inhibitors associated with cerebral ischemic stroke in young patients with sickle cell anemia
CONCLUSION: The findings of this study, the SNPs, and expression provide initial support for understanding the role of MMPs-TIMPs in the pathophysiology of SCA in young patients.PMID:36720795 | DOI:10.1007/s11033-023-08262-2
Source: Molecular Biology Reports - January 31, 2023 Category: Molecular Biology Authors: Ó do Kleyton Palmeira Ana Karla da Silva Freire D ébora Nascimento de Nóbrega Roberta Dos Santos Souza Isabela Cristina Cordeiro Farias Taciana Furtado de Mendon ça Belmont Andreia Soares da Silva Gabriela da Silva Arcanjo Aderson da Silva Araujo Ana Source Type: research

Association between dyslipidemia and CCL2 in patients undergoing hemodialysis.
CONCLUSION: Our findings show that CCL2 levels are associated with dyslipidemia, which suggests a role of this cytokine in the pathogenesis of cardiovascular disease in HD patients. A better understanding of this pathogenesis could contribute to the discovery of new therapeutic targets that would reduce cardiovascular complications in these patients. PMID: 31557637 [PubMed - as supplied by publisher]
Source: Cytokine - September 22, 2019 Category: Molecular Biology Authors: de Oliveira Junior WV, Silva APF, de Figueiredo RC, Gomes KB, Simões E Silva AC, Dusse LMS, Rios DRA Tags: Cytokine Source Type: research

Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients
AbstractAnticoagulant and antiplatelet drugs effectively prevent thrombotic events in patients with cardiovascular diseases, ischemic stroke, peripheral vascular diseases, and other thromboembolic diseases. However, genetic and non-genetic factors affect the response to antithrombotic therapy and can increase the risk of adverse events. This narrative review discusses pharmacogenomic studies on antithrombotic drugs commonly prescribed in Brazil. Multiple Brazilian studies assessed the impact of pharmacokinetic (PK) and pharmacodynamic (PD) gene variants on warfarin response. The reduced function allelesCYP2C9*2 andCYP2C9*3...
Source: Molecular Diagnosis and Therapy - August 6, 2021 Category: Molecular Biology Source Type: research