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Lack of seroprotection against diphtheria in the Austrian population, in light of reported diphtheria cases in Europe, 2022
Euro Surveill. 2023 Apr;28(17). doi: 10.2807/1560-7917.ES.2023.28.17.2300206.ABSTRACTFollowing an increase in diphtheria cases in Europe since 2022, we retrospectively estimated the prevalence of seroprotection against diphtheria and tetanus in 10,247 Austrian residents (population: 8,978,929) voluntarily tested between 2018 and 2022. Lack of seroprotection against diphtheria was found in 36% compared with 4% against tetanus. The geometric mean antibody concentration against tetanus was 7.9-fold higher compared with that for diphtheria. Raising awareness of regular booster vaccinations against diphtheria in combination wit...
Source: Euro Surveill - April 27, 2023 Category: Infectious Diseases Authors: Angelika Wagner Joanna Jasinska Daniela Schmid Michael Kundi Ursula Wiedermann Source Type: research

Isolate-Based Surveillance of Bordetella pertussis, Austria, 2018-2020
We describe a novel pertussis isolate-based surveillance system and a core genome multilocus sequence typing scheme to assess Bordetella pertussis genetic variability and investigate the increased incidence of pertussis in Austria. During 2018-2020, we obtained 123 B. pertussis isolates and typed them with the new scheme (2,983 targets and preliminary cluster threshold of <6 alleles). B. pertussis isolates in Austria differed genetically from the vaccine strain, both in their core genomes and in their vaccine antigen genes; 31.7% of the isolates were pertactin-deficient. We detected 8 clusters, 1 of them with pertactin-...
Source: Emerging Infectious Diseases - February 24, 2021 Category: Infectious Diseases Authors: Adriana Cabal Daniela Schmid Markus Hell Ali Chakeri Elisabeth Mustafa-Korninger Alexandra Wojna Anna St öger Johannes M öst Eva Leitner Patrick Hyden Thomas Rattei Adele Habington Ursula Wiedermann Franz Allerberger Werner Ruppitsch Source Type: research