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Tracking contaminants of concern in wet-weather sanitary sewer overflows
The objective was to identify the risks posed by sewage contaminants to aquatic biota in the receiving waters, to aid in prioritising management actions. Twelve organic contaminants were identified in influents across the four sites under rainfall ingress diluted conditions, with measurements showing that the highest concentrations were restricted to the anti-inflammatory acetaminophen and the diabetes medication metformin. Lesser contaminants included theobromine, ibuprofen, sucralose, and three benzotriazoles (mainly 1-H benzotriazole). An assessment of the toxicity of the identified organic chemicals indicated that none...
Source: Environmental Science and Pollution Research International - August 15, 2023 Category: Environmental Health Authors: Colin H Besley Graeme E Batley Michele Cassidy Source Type: research

Acetaminophen metabolites on presentation following an acute acetaminophen overdose (ATOM-7)
This study found that those who developed hepatotoxicity had higher acetaminophen metabolites derived from CYP pathway and lower sulfation metabolite on presentation. Acetaminophen metabolites may be utilised in the future to identify patients who could benefit from increased acetylcysteine or newer adjunct or research therapies.PMID:36919638 | DOI:10.1002/cpt.2888
Source: Clinical Pharmacology and Therapeutics - March 15, 2023 Category: Drugs & Pharmacology Authors: Angela L Chiew Geoffrey K Isbister Paul Stathakis Katherine Z Isoardi Colin Page Kirsty Ress Betty Sh Chan Nicholas A Buckley Source Type: research

LITFL Review 312
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Welcome to the 312nd LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM. The Most Fair Dinkum Ripper Beauts of the Week SGEM often posts thoughtful “skeptical” reviews on logical-sounding procedures a...
Source: Life in the Fast Lane - December 25, 2017 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs

Paracetamol (acetaminophen) for chronic non-cancer pain in children and adolescents.
CONCLUSIONS: There was no evidence from randomised controlled trials to support or refute the use of paracetamol (acetaminophen) to treat chronic non-cancer pain in children and adolescents. We are unable to comment about efficacy or harm from the use of paracetamol to treat chronic non-cancer pain in children and adolescents.We know from adult randomised controlled trials that paracetamol, can be effective, in certain doses, and in certain pain conditions (not always chronic).This means that no conclusions could be made about efficacy or harm in the use of paracetamol (acetaminophen) to treat chronic non-cancer pain in ch...
Source: Cochrane Database of Systematic Reviews - August 2, 2017 Category: General Medicine Authors: Cooper TE, Fisher E, Anderson B, Wilkinson NM, Williams DG, Eccleston C Tags: Cochrane Database Syst Rev Source Type: research